HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: FAK1 (Q05397)
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
Gene: PTK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.900

Property	Details
Experiments	14517242, 18031698, 25416956, 16007195
Identification Methods	pull down, far western blotting, affinity chromatography technology, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1052
+	Hs
		433329 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FAK1_HUMAN (1-1052): 0: 1127: 100.00
+	Mm
		193375 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		FAK1_MOUSE (1-1052): 0: 1121: 97.34
+	Hs
		147424 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		FAK2_HUMAN (35-1043): 0: 852: 44.78
+	Hs
		111145 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		I6L996_HUMAN (391-1052): 0: 645: 99.40
+	Hs
		111147 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		I6L996_HUMAN (391-1052): 0: 645: 99.40
+	Hs
		992596 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		ACK1_HUMAN (386-1032): 6.61e-120: 395: 22.90
+	Hs
		146662 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		M3K7_HUMAN (416-1020): 6.5e-124: 393: 21.16
+	Hs
		433265 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		EPHB2_HUMAN (383-823): 1.06e-119: 395: 28.70
+	Hs
		433331 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ACK1_HUMAN (386-1032): 6.61e-120: 395: 22.90
+	Hs
		147365 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		M3K7_HUMAN (416-1020): 6.5e-124: 393: 21.16
+	Hs
		411946 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FYN_HUMAN (265-689): 7.19e-119: 377: 26.68
+	Hs
		433229 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FGFR1_HUMAN (331-734): 2.82e-114: 374: 27.64
+	Hs
		433231 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		SRC_HUMAN (415-689): 1.19e-113: 363: 38.77
+	Hs
		146668 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		YES_HUMAN (415-689): 7.31e-112: 359: 37.68
+	Hs
		147377 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		YES_HUMAN (415-689): 7.31e-112: 359: 37.68
+	Hs
		433215 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		YES_HUMAN (415-689): 7.31e-112: 359: 37.68
+	Hs
		147374 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		LCK_HUMAN (412-691): 7.42e-111: 355: 37.37
+	Hs
		411552 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		LCK_HUMAN (412-691): 7.42e-111: 355: 37.37
+	Hs
		147427 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		ERBB4_HUMAN (408-695): 1.19e-58: 222: 39.53
+	Hs
		433359 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		ERBB4_HUMAN (408-695): 1.19e-58: 222: 39.53