HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: CSF3R (Q99062)
Granulocyte colony-stimulating factor receptor (G-CSF receptor) (G-CSF-R) (CD antigen CD114)
Gene: CSF3R

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	12133942
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 836
+	Hs
		442875 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		CSF3R_HUMAN (1-836): 2.01e-167: 508: 100.00
+	Hs
		433961 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		CSF3R_HUMAN (1-836): 2.01e-167: 508: 100.00
+	Mm
		435879 HCK_MOUSE (14-223): 4.94e-46: 161: 15.04		CSF3R_MOUSE (1-836): 1.78e-153: 472: 60.29
+	Mm
		193384 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		IL6RB_MOUSE (12-777): 4.57e-116: 376: 25.44
+	Hs
		147443 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		I12R2_HUMAN (5-826): 2.03e-108: 354: 21.24
+	Hs
		147398 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IL6RB_HUMAN (8-802): 1.15e-97: 327: 23.48
+	Hs
		442787 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		IL6RB_HUMAN (8-802): 1.15e-97: 327: 23.48
+	Hs
		412016 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		PTPRD_HUMAN (19-784): 1.83e-50: 195: 13.96
+	Hs
		147385 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		PRLR_HUMAN (121-341): 1.45e-46: 178: 24.14
+	Mm
		56907 FYN_MOUSE (35-223): 5.56e-48: 166: 13.90		PTPRF_MOUSE (3-571): 2.93e-45: 179: 13.36
+	Hs
		411959 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		PTPRF_HUMAN (3-547): 3.25e-41: 166: 11.65
+	Hs
		411565 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		PTPRF_HUMAN (3-547): 3.25e-41: 166: 11.65
+	Hs
		434019 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		ROBO2_HUMAN (18-805): 7.22e-26: 117: 12.97
+	Mm
		193379 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		LEPR_MOUSE (66-329): 2.7e-16: 86.1: 18.56
+	Mm
		817307 SOCS7_MOUSE (13-221): 4.57e-51: 175: 24.17		LEPR_MOUSE (66-329): 2.7e-16: 86.1: 18.56
+	Mm
		817309 SOCS6_MOUSE (34-220): 9.75e-49: 168: 26.32		LEPR_MOUSE (66-329): 2.7e-16: 86.1: 18.56
+	Hs
		147403 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		LEPR_HUMAN (83-329): 2.37e-13: 76.4: 15.94
+	Mm
		817306 CISH_MOUSE (13-221): 1.36e-46: 156: 29.86		LEPR_MOUSE (66-329): 2.7e-16: 86.1: 18.56
+	Mm
		193361 SOCS2_MOUSE (3-221): 2.11e-46: 154: 28.31		LEPR_MOUSE (66-329): 2.7e-16: 86.1: 18.56
+	Hs
		433804 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		SDK2_HUMAN (179-610): 5.91e-11: 68.7: 13.82