HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: SH22A (Q9NP31)
SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
Gene: SH2D2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 225 Hs			1 389
+	Mm
		536205 FGR_MOUSE (35-223): 1.31e-48: 168: 14.55		FGR_MOUSE (10-211): 1.59e-51: 181: 17.49
+	Hs
		433222 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FGR_HUMAN (6-258): 5.75e-49: 175: 15.64
+	Hs
		924732 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		433231 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Hs
		146674 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		433216 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		146668 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		YES_HUMAN (7-280): 2.56e-46: 168: 16.56
+	Hs
		147377 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		YES_HUMAN (7-280): 2.56e-46: 168: 16.56
+	Hs
		433280 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		CRKL_HUMAN (95-347): 5.6e-49: 169: 21.76
+	Hs
		454787 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		FGR_HUMAN (6-258): 5.75e-49: 175: 15.64
+	Hs
		433215 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		YES_HUMAN (7-280): 2.56e-46: 168: 16.56
+	Mm
		193378 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		CRKL_MOUSE (95-347): 4.62e-47: 164: 22.14
+	Hs
		147374 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31
+	Hs
		411946 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Hs
		433535 FGR_HUMAN (35-219): 3.21e-48: 167: 14.35		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		411552 YES_HUMAN (35-223): 2.84e-50: 173: 14.55		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31
+	Mm
		411932 SOCS6_MOUSE (34-220): 9.75e-49: 168: 26.32		LCK_MOUSE (50-210): 2.53e-44: 162: 20.00
+	Hs
		147422 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		PTK6_HUMAN (84-194): 4.58e-32: 127: 28.93
+	Mm
		536207 FGR_MOUSE (35-223): 1.31e-48: 168: 14.55		KSYK_MOUSE (95-213): 1.04e-17: 86.9: 25.60