HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: RBX2 (Q9UBF6)
RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein)
Gene: RNF7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	24438103, 15601820
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 225 Hs			1 113
+	Hs
		1263837 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Mm
		193396 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		RBX2_MOUSE (1-113): 2.07e-33: 114: 96.46
+	Hs
		146699 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		256860 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		146650 SOCS2_HUMAN (3-221): 1.16e-46: 154: 28.31		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		1345543 CISH_HUMAN (13-221): 1.55e-45: 153: 30.62		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		147569 SOCS6_HUMAN (15-220): 4.58e-39: 143: 22.64		RBX2_HUMAN (1-113): 1.25e-33: 114: 100.00
+	Hs
		181836 SOCS1_HUMAN (19-221): 4.01e-37: 130: 25.98		RBX1_HUMAN (18-112): 5.7e-38: 125: 46.94
+	Hs
		412267 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		RN149_HUMAN (44-112): 2.28e-17: 77.5: 24.64
+	Hs
		782806 CSK_HUMAN (3-220): 3.6e-38: 139: 12.45		RN149_HUMAN (44-112): 2.28e-17: 77.5: 24.64