HitPredict

Interactor 1: SOCS6 (O14544)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Interactor 2: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.887

Property	Details
Experiments	25402006, 24658140, 22973453, unassigned2173
Identification Methods	two hybrid, protein complementation assay, pull down, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 1210
+	Hs
		147522 SOCS6_HUMAN (1-535): 0: 701: 100.00		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		147470 SOCS6_HUMAN (1-535): 0: 701: 100.00		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		147483 SOCS6_HUMAN (1-535): 0: 701: 100.00		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		337804 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		337769 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		EGFR_HUMAN (1-1210): 0: 1241: 100.00
+	Hs
		442833 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		ERBB4_HUMAN (1-1199): 0: 1137: 49.46
+	Hs
		383547 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		383528 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		ERBB2_HUMAN (5-1200): 0: 1111: 48.49
+	Hs
		442779 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		411594 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		ERBB3_HUMAN (1-1210): 0: 1080: 40.95
+	Hs
		147489 SOCS6_HUMAN (1-535): 0: 701: 100.00		EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79
+	Hs
		147471 SOCS6_HUMAN (1-535): 0: 701: 100.00		INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87
+	Hs
		411611 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79
+	Hs
		442817 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58
+	Hs
		442812 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68
+	Hs
		442789 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		ABL2_HUMAN (707-974): 5.53e-52: 202: 40.37
+	Hs
		111146 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		I6L996_HUMAN (716-991): 1.12e-54: 205: 37.68
+	Hs
		411633 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70
+	Hs
		411632 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		ZAP70_HUMAN (718-961): 5.57e-53: 199: 39.59
+	Dm
		382221 SRC42_DROME (286-502): 8.85e-59: 205: 18.70		EGFR_DROME (30-339): 1.78e-25: 116: 21.28