HitPredict

Interactor 1: SOCS6 (O14544)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0009968 - negative regulation of signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 1342
+	Hs
		147522 SOCS6_HUMAN (1-535): 0: 701: 100.00		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		147470 SOCS6_HUMAN (1-535): 0: 701: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		147469 SOCS6_HUMAN (1-535): 0: 701: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		442779 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		411594 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		442833 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		383547 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		383528 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337804 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337769 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		147489 SOCS6_HUMAN (1-535): 0: 701: 100.00		EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40
+	Hs
		147492 SOCS6_HUMAN (1-535): 0: 701: 100.00		TXK_HUMAN (707-969): 2.69e-44: 171: 37.12
+	Hs
		147471 SOCS6_HUMAN (1-535): 0: 701: 100.00		INSR_HUMAN (329-650): 2.27e-22: 106: 16.98
+	Hs
		337315 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		442817 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		ACK1_HUMAN (683-961): 1.22e-46: 184: 38.73
+	Hs
		442789 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06
+	Hs
		442812 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		FAK1_HUMAN (713-992): 4.43e-41: 167: 32.19
+	Dm
		1360389 SRC42_DROME (286-502): 8.85e-59: 205: 18.70		SRC42_DROME (707-961): 1.65e-42: 166: 37.07
+	Hs
		111146 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		I6L996_HUMAN (713-992): 1.5e-41: 166: 32.19
+	Dm
		382221 SRC42_DROME (286-502): 8.85e-59: 205: 18.70		EGFR_DROME (347-637): 4.79e-14: 79.5: 20.27