HitPredict

Interactor 1: SOCS6 (O14544)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 694
+	Hs
		442825 HCK_HUMAN (236-495): 1.34e-58: 205: 15.16		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		411709 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		209049 NCK2_HUMAN (182-466): 4.45e-53: 186: 17.04		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		433345 YES_HUMAN (324-495): 7.66e-51: 184: 14.92		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		522965 SRC_HUMAN (257-495): 1.3e-50: 183: 15.48		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Mm
		403466 SRC_MOUSE (250-495): 4.17e-51: 185: 14.84		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		846468 BLK_HUMAN (301-495): 4.58e-47: 173: 16.13		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		1035381 TENS3_HUMAN (161-475): 7.47e-45: 171: 18.08		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		433750 LYN_HUMAN (292-495): 1.72e-46: 171: 14.82		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		523213 SRC_HUMAN (257-495): 1.3e-50: 183: 15.48		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Mm
		639464 LYN_MOUSE (292-495): 2.8e-46: 171: 15.28		GAB2_MOUSE (3-691): 8.7e-141: 429: 38.33
+	Hs
		412280 FYN_HUMAN (324-506): 2.87e-51: 185: 15.63		GAB3_HUMAN (1-683): 1.81e-103: 329: 28.82
+	Hs
		523086 SRC_HUMAN (257-495): 1.3e-50: 183: 15.48		GAB3_HUMAN (1-683): 1.81e-103: 329: 28.82
+	Hs
		433922 LYN_HUMAN (292-495): 1.72e-46: 171: 14.82		GAB3_HUMAN (1-683): 1.81e-103: 329: 28.82
+	Hs
		411764 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		433388 YES_HUMAN (324-495): 7.66e-51: 184: 14.92		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		411861 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		433831 LYN_HUMAN (292-495): 1.72e-46: 171: 14.82		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		411897 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		PKHA6_HUMAN (5-495): 5.54e-58: 214: 13.33
+	Hs
		297808 LYN_HUMAN (292-495): 1.72e-46: 171: 14.82		K0754_HUMAN (339-656): 1.08e-09: 64.4: 11.22