HitPredict

Interactor 1: SOCS6 (O14544)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Interactor 2: WDTC1 (Q8N5D0)
WD and tetratricopeptide repeats protein 1
Gene: WDTC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	28883622, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 535 Hs			1 677
+	Hs
		146638 SOCS2_HUMAN (344-535): 7.98e-46: 161: 30.81		WDTC1_HUMAN (1-677): 4.96e-133: 408: 100.00
+	Hs
		411887 LCK_HUMAN (258-495): 3.81e-54: 192: 17.20		CHIP_HUMAN (357-493): 1.72e-38: 146: 30.66
+	Hs
		412410 FYN_HUMAN (324-506): 2.87e-51: 185: 15.63		CHIP_HUMAN (357-493): 1.72e-38: 146: 30.66
+	Mm
		403469 SRC_MOUSE (250-495): 4.17e-51: 185: 14.84		CHIP_MOUSE (357-493): 8.17e-38: 144: 29.20
+	Hs
		523205 SRC_HUMAN (257-495): 1.3e-50: 183: 15.48		CHIP_HUMAN (357-493): 1.72e-38: 146: 30.66
+	Hs
		454816 FGR_HUMAN (324-495): 7.68e-48: 175: 17.03		COPA_HUMAN (261-665): 6.18e-29: 125: 10.07
+	Hs
		412300 FYN_HUMAN (324-506): 2.87e-51: 185: 15.63		SNR40_HUMAN (5-71): 6.38e-13: 72.5: 22.39
+	Hs
		1135821 P55G_HUMAN (380-505): 3.47e-19: 92.1: 26.19		DCAF8_HUMAN (511-677): 1.89e-31: 131: 29.15
+	Hs
		655507 P85A_HUMAN (384-496): 1.31e-12: 72.4: 23.89		CHIP_HUMAN (357-493): 1.72e-38: 146: 30.66
+	Hs
		655283 P85A_HUMAN (384-496): 1.31e-12: 72.4: 23.89		COPA_HUMAN (261-665): 6.18e-29: 125: 10.07