HitPredict

Interactor 1: HSPB6 (O14558)
Heat shock protein beta-6 (HspB6) (Heat shock 20 kDa-like protein p20) (Heat shock protein family B member 6)
Gene: HSPB6

Interactor 2: BAG3 (O95817)
BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1)
Gene: BAG3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	26186194, 28514442, 33961781, 23824909
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process GO:0051087 - protein-folding chaperone binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 160 Hs			1 575
+	Hs
		324154 CRYAA_HUMAN (3-160): 9.34e-55: 172: 37.13		BAG3_HUMAN (1-575): 0: 809: 100.00
+	Hs
		324155 CRYAB_HUMAN (3-155): 7.11e-50: 159: 44.65		BAG3_HUMAN (1-575): 0: 809: 100.00
+	Hs
		324160 HSPB1_HUMAN (2-155): 4.74e-47: 153: 31.43		BAG3_HUMAN (1-575): 0: 809: 100.00
+	Hs
		324673 HSPB8_HUMAN (2-159): 1.23e-37: 129: 26.40		BAG3_HUMAN (1-575): 0: 809: 100.00
+	Hs
		324422 HSPB2_HUMAN (20-148): 9.31e-36: 123: 42.22		BAG3_HUMAN (1-575): 0: 809: 100.00
+	Mm
		1337503 HSPB8_MOUSE (2-159): 3.17e-36: 125: 28.09		BAG3_MOUSE (1-575): 0: 762: 83.31
+	Dm
		65603 HSP6C_DROME (69-157): 2.21e-29: 108: 40.86		A8JNS4_DROME (398-498): 1.33e-26: 116: 32.11
+	Dm
		65596 M9NHC5_DROME (61-150): 9.37e-29: 105: 38.89		A8JNS4_DROME (398-498): 1.33e-26: 116: 32.11
+	Dm
		1374285 Q9VWG1_DROME (44-150): 4.12e-28: 104: 33.65		Q9VU81_DROME (398-498): 1.2e-26: 116: 32.11