HitPredict

Interactor 1: HSPB6 (O14558)
Heat shock protein beta-6 (HspB6) (Heat shock 20 kDa-like protein p20) (Heat shock protein family B member 6)
Gene: HSPB6

Interactor 2: HSPB8 (Q9UJY1)
Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Heat shock protein family B member 8) (Protein kinase H11) (Small stress protein-like protein HSP22)
Gene: HSPB8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	16225851
Identification Methods	two hybrid, fluorescent resonance energy transfer
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Crystallin~HSP20, HSP20~HSP20
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042803 - protein homodimerization activity
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 160 Hs			1 196
+	Hs
		359087 CRYAB_HUMAN (3-155): 7.11e-50: 159: 44.65		HSPB8_HUMAN (1-196): 7.92e-71: 214: 100.00
+	Hs
		358699 CRYAA_HUMAN (3-160): 9.34e-55: 172: 37.13		HSPB1_HUMAN (1-179): 9.77e-63: 194: 36.67
+	Hs
		147844 HSPB6_HUMAN (1-144): 1.93e-50: 160: 100.00		HSPB1_HUMAN (1-179): 9.77e-63: 194: 36.67
+	Hs
		358950 CRYAB_HUMAN (3-155): 7.11e-50: 159: 44.65		HSPB1_HUMAN (1-179): 9.77e-63: 194: 36.67
+	Rn
		621311 CRYAB_RAT (3-155): 3.9e-51: 162: 45.28		HSPB1_RAT (1-179): 4.16e-61: 190: 36.41
+	Hs
		358697 CRYAA_HUMAN (3-160): 9.34e-55: 172: 37.13		CRYAB_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Hs
		358941 CRYAA_HUMAN (3-160): 9.34e-55: 172: 37.13		V9HW27_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Hs
		358696 CRYAA_HUMAN (3-160): 9.34e-55: 172: 37.13		CRYAA_HUMAN (6-187): 8.59e-53: 168: 23.53
+	Bt
		358695 CRYAA_BOVIN (3-160): 2.94e-53: 168: 36.53		CRYAB_BOVIN (6-187): 1.45e-53: 170: 31.15
+	Hs
		147843 HSPB6_HUMAN (1-144): 1.93e-50: 160: 100.00		CRYAB_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Hs
		1378434 V9HW27_HUMAN (3-155): 7.11e-50: 159: 44.65		V9HW27_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Hs
		358943 CRYAB_HUMAN (3-155): 7.11e-50: 159: 44.65		CRYAB_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Hs
		358767 CRYAA_HUMAN (3-160): 9.34e-55: 172: 37.13		HSPB2_HUMAN (1-170): 5.01e-42: 141: 25.88
+	Rn
		956843 HSPB6_RAT (1-160): 4.55e-52: 164: 89.51		HSPB6_RAT (5-168): 1.62e-43: 144: 30.12
+	Hs
		359021 CRYAB_HUMAN (3-155): 7.11e-50: 159: 44.65		HSPB2_HUMAN (1-170): 5.01e-42: 141: 25.88