HitPredict

Interactor 1: DC1I1 (O14576)
Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1)
Gene: DYNC1I1

Interactor 2: DC1L2 (O43237)
Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55)
Gene: DYNC1LI2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 28718761, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000776 - kinetochore GO:0005829 - cytosol GO:0005868 - cytoplasmic dynein complex GO:0005874 - microtubule GO:0045504 - dynein heavy chain binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 645 Hs			1 492
+	Hs
		198252 DC1I2_HUMAN (1-645): 4.95e-134: 408: 74.88		DC1L2_HUMAN (1-492): 0: 812: 100.00
+	Hs
		148125 DC1I1_HUMAN (1-645): 7.32e-150: 450: 100.00		DC1L1_HUMAN (2-492): 0: 766: 62.43
+	Hs
		1033364 DC1I2_HUMAN (1-645): 4.95e-134: 408: 74.88		DC1L1_HUMAN (2-492): 0: 766: 62.43
+	Hs
		198239 WDR5_HUMAN (135-467): 5.01e-40: 151: 11.18		DC1L2_HUMAN (1-492): 0: 812: 100.00
+	Hs
		198230 LIS1_HUMAN (11-371): 4.83e-19: 91.8: 9.46		DC1L2_HUMAN (1-492): 0: 812: 100.00
+	Hs
		793049 LIS1_HUMAN (11-371): 4.83e-19: 91.8: 9.46		DC1L1_HUMAN (2-492): 0: 766: 62.43
+	Dm
		1096835 DYIN_DROME (6-635): 2.04e-103: 330: 46.46		Q8IR93_DROME (101-489): 0: 527: 41.42
+	Hs
		1022892 STRN3_HUMAN (364-625): 1.19e-14: 79.6: 13.60		DC1L1_HUMAN (2-492): 0: 766: 62.43
+	Ce
		105732 LIN53_CAEEL (257-617): 1.39e-64: 220: 16.40		G5ED34_CAEEL (25-484): 7.91e-165: 475: 29.29