HitPredict

Interactor 1: DC1I1 (O14576)
Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1)
Gene: DYNC1I1

Interactor 2: DYL1 (P63167)
Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN)
Gene: DYNLL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.891

Property	Details
Experiments	20921139, 12475239, 33961781, 11148209
Identification Methods	affinity chromatography technology, two hybrid, pull down, unspecified method, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Dynein_IC2~Dynein_light
Common GO terms	GO:0000776 - kinetochore GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005868 - cytoplasmic dynein complex and 1 others more... GO:0005874 - microtubule
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 645 Hs			1 89
+	Hs
		148093 DC1I1_HUMAN (1-645): 7.32e-150: 450: 100.00		DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26
+	Mm
		291681 DC1I1_MOUSE (1-645): 1.63e-144: 435: 95.35		DYL1_MOUSE (1-89): 1.96e-46: 145: 100.00
+	Hs
		928281 DC1I2_HUMAN (1-645): 4.95e-134: 408: 74.88		DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00
+	Hs
		1033319 DC1I2_HUMAN (1-645): 4.95e-134: 408: 74.88		DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26
+	Dm
		1096026 DYIN_DROME (6-635): 2.04e-103: 330: 46.46		DYL1_DROME (1-89): 1.36e-46: 145: 94.38
+	Ce
		219878 O45087_CAEEL (7-636): 9.6e-93: 301: 34.20		DYL1_CAEEL (1-89): 8.25e-46: 143: 92.14
+	Hs
		928412 DC2I1_HUMAN (25-637): 3.74e-80: 276: 15.32		DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00
+	Hs
		1261759 DC2I1_HUMAN (25-637): 3.74e-80: 276: 15.32		DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26
+	Hs
		928426 DC2I2_HUMAN (206-608): 5.88e-80: 264: 20.46		DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00
+	Hs
		1290452 DC2I2_HUMAN (206-608): 5.88e-80: 264: 20.46		DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26
+	Cr
		65477 A8IJZ3_CHLRE (157-608): 1.49e-86: 283: 22.20		A8IRP4_CHLRE (13-88): 3.51e-26: 94.7: 43.37
+	Hs
		792964 LIS1_HUMAN (11-371): 4.83e-19: 91.8: 9.46		DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00
+	Hs
		793023 LIS1_HUMAN (11-371): 4.83e-19: 91.8: 9.46		DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26
+	Hs
		928277 STRN3_HUMAN (364-625): 1.19e-14: 79.6: 13.60		DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00
+	Hs
		1022851 STRN3_HUMAN (364-625): 1.19e-14: 79.6: 13.60		DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26