Interactor 1: FOB1 (O13329)
DNA replication fork-blocking protein FOB1
Gene: FOB1
Interactor 2: SIR2 (P06700)
NAD-dependent histone deacetylase SIR2 (EC 2.3.1.286) (Regulatory protein SIR2) (Silent information regulator 2)
Gene: SIR2
Species: Saccharomyces cerevisiae S288C
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.90 | 0.55 | 0.706 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26063576, 12923057, 26951198, 20179323, 22362748, 17043313, 21179020 |
| Identification Methods | pull down, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, tandem affinity purification |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0000183 - rDNA heterochromatin formation GO:0005730 - nucleolus GO:0006325 - chromatin organization GO:0008156 - negative regulation of DNA replication |
| Homologous interactions | 0 |
Service provided by Combinatics, Japan
Last updated: 11Aug2025
