HitPredict

Interactor 1: UTY (O14607)
Histone demethylase UTY (EC 1.14.11.68) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase UTY)
Gene: UTY

Interactor 2: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	TPR_16~WD40
Common GO terms	GO:0005654 - nucleoplasm GO:0044666 - MLL3/4 complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1347 Hs			1 538
+	Hs
		183118 KDM6A_HUMAN (1-1347): 0: 1425: 83.29		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Hs
		150096 UTY_HUMAN (1-1340): 0: 1481: 100.00		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		183146 KDM6A_HUMAN (1-1347): 0: 1425: 83.29		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		99745 F5H5V6_HUMAN (1-1347): 0: 1430: 84.04		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		183095 KDM6A_HUMAN (1-1347): 0: 1425: 83.29		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Mm
		1129461 KDM6B_MOUSE (508-1345): 0: 863: 42.69		RBBP5_MOUSE (1-538): 9.56e-137: 408: 99.07
+	Hs
		165853 KDM6B_HUMAN (391-1345): 0: 859: 38.61		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Hs
		165835 KDM6B_HUMAN (391-1345): 0: 859: 38.61		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Ce
		1089275 JMJ31_CAEEL (541-1337): 0: 678: 21.85		WDR51_CAEEL (140-424): 4.13e-47: 170: 13.29
+	Hs
		174908 OGT1_HUMAN (165-614): 1.63e-32: 139: 10.07		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Dm
		114497 M9PCJ7_DROME (9-155): 3.25e-10: 67: 17.69		RBBP5_DROME (1-494): 3.54e-103: 320: 65.79
+	Ca
		483035 Q5ADP3_CANAL (273-459): 2.31e-16: 87: 18.18		TUP1_CANAL (100-402): 3.81e-53: 190: 16.10
+	Sp
		224208 CYC8_SCHPO (233-962): 5.09e-42: 170: 13.14		TUP12_SCHPO (226-339): 4.64e-10: 64.3: 18.33
+	Sp
		224207 CYC8_SCHPO (233-962): 5.09e-42: 170: 13.14		TUP11_SCHPO (2-58): 7.11e-09: 60.4: 14.04
+	Hs
		174768 OGT1_HUMAN (165-614): 1.63e-32: 139: 10.07		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		1056932 MDC1_HUMAN (457-1023): 4.41e-15: 83.1: 11.02		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		1056974 MDC1_HUMAN (457-1023): 4.41e-15: 83.1: 11.02		WDR33_HUMAN (198-342): 2.09e-17: 88.1: 10.67
+	Dm
		114491 M9PCJ7_DROME (9-155): 3.25e-10: 67: 17.69		WDS_DROME (250-438): 1.02e-21: 98.5: 10.82