HitPredict

Interactor 1: CXL11 (O14625)
C-X-C motif chemokine 11 (Beta-R1) (H174) (Interferon gamma-inducible protein 9) (IP-9) (Interferon-inducible T-cell alpha chemoattractant) (I-TAC) (Small-inducible cytokine B11)
Gene: CXCL11

Interactor 2: CXCR3 (P49682)
C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183)
Gene: CXCR3

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.814

Property	Details
Experiments	12782716, 9625760, 11259614
Identification Methods	pull down, experimental interaction detection, biochemical
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0051281 - positive regulation of release of sequestered calcium ion into cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 94 Hs			1 368
+	Hs
		150319 CXL11_HUMAN (1-94): 1.5e-27: 97.8: 100.00		CCR3_HUMAN (43-336): 1.14e-80: 252: 33.45
+	Hs
		364107 CXL10_HUMAN (1-93): 5.22e-27: 96.3: 31.18		CCR3_HUMAN (43-336): 1.14e-80: 252: 33.45
+	Hs
		364105 CXL10_HUMAN (1-93): 5.22e-27: 96.3: 31.18		CXCR3_HUMAN (1-368): 8.13e-79: 247: 100.00
+	Hs
		486185 IL8_HUMAN (14-92): 3.1e-23: 87: 21.95		CXCR2_HUMAN (25-363): 2.48e-82: 256: 40.35
+	Hs
		486184 IL8_HUMAN (14-92): 3.1e-23: 87: 21.95		CXCR1_HUMAN (20-351): 4.45e-82: 255: 38.12
+	Hs
		587767 CXCL2_HUMAN (19-91): 1.84e-22: 85.1: 31.51		CXCR2_HUMAN (25-363): 2.48e-82: 256: 40.35
+	Hs
		625748 CXCL5_HUMAN (16-90): 1.53e-21: 83.2: 24.00		CXCR2_HUMAN (25-363): 2.48e-82: 256: 40.35
+	Hs
		625736 CXCL5_HUMAN (16-90): 1.53e-21: 83.2: 24.00		CXCR1_HUMAN (20-351): 4.45e-82: 255: 38.12
+	Hs
		364042 CXCL7_HUMAN (24-90): 5.74e-21: 82: 25.37		CXCR2_HUMAN (25-363): 2.48e-82: 256: 40.35
+	Hs
		448988 GROA_HUMAN (24-93): 3.65e-21: 82: 30.00		CXCR2_HUMAN (25-363): 2.48e-82: 256: 40.35
+	Hs
		587786 CXCL3_HUMAN (24-92): 5.01e-21: 81.6: 31.88		CXCR2_HUMAN (25-363): 2.48e-82: 256: 40.35
+	Hs
		364041 CXCL7_HUMAN (24-90): 5.74e-21: 82: 25.37		CXCR1_HUMAN (20-351): 4.45e-82: 255: 38.12
+	Hs
		448987 GROA_HUMAN (24-93): 3.65e-21: 82: 30.00		CXCR1_HUMAN (20-351): 4.45e-82: 255: 38.12
+	Hs
		625737 CXCL6_HUMAN (17-90): 2.68e-20: 79.7: 25.68		CXCR1_HUMAN (20-351): 4.45e-82: 255: 38.12
+	Mm
		291524 CXL10_MOUSE (1-93): 1.92e-29: 102: 33.33		CXCR3_MOUSE (1-368): 1.26e-72: 232: 86.41
+	Hs
		849615 CXCL9_HUMAN (20-90): 3.13e-20: 80.1: 40.85		CCR3_HUMAN (43-336): 1.14e-80: 252: 33.45
+	Mm
		291525 CXCL9_MOUSE (1-90): 1.78e-27: 98.6: 28.89		CXCR3_MOUSE (1-368): 1.26e-72: 232: 86.41
+	Hs
		830623 CXCL9_HUMAN (20-90): 3.13e-20: 80.1: 40.85		CXCR3_HUMAN (1-368): 8.13e-79: 247: 100.00
+	Mm
		500672 CXCL2_MOUSE (17-92): 5.79e-24: 88.9: 28.95		CXCR2_MOUSE (12-351): 3.11e-65: 212: 34.11
+	Mm
		522397 GROA_MOUSE (20-91): 5.74e-23: 86.2: 26.39		CXCR2_MOUSE (12-351): 3.11e-65: 212: 34.11