HitPredict

Interactor 1: CXL11 (O14625)
C-X-C motif chemokine 11 (Beta-R1) (H174) (Interferon gamma-inducible protein 9) (IP-9) (Interferon-inducible T-cell alpha chemoattractant) (I-TAC) (Small-inducible cytokine B11)
Gene: CXCL11

Interactor 2: CCR3 (P51677)
C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)
Gene: CCR3

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.24	1.00	0.492

Property	Details
Experiments	11110785
Identification Methods	experimental interaction detection
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 94 Hs			1 355
+	Mm
		500672 CXCL2_MOUSE (17-92): 5.79e-24: 88.9: 28.95		CXCR2_MOUSE (20-323): 7e-83: 257: 30.82
+	Hs
		364107 CXL10_HUMAN (1-93): 5.22e-27: 96.3: 31.18		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Mm
		522397 GROA_MOUSE (20-91): 5.74e-23: 86.2: 26.39		CXCR2_MOUSE (20-323): 7e-83: 257: 30.82
+	Hs
		849615 CXCL9_HUMAN (20-90): 3.13e-20: 80.1: 40.85		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Mm
		291524 CXL10_MOUSE (1-93): 1.92e-29: 102: 33.33		CXCR3_MOUSE (36-318): 4.07e-45: 160: 36.36
+	Mm
		291525 CXCL9_MOUSE (1-90): 1.78e-27: 98.6: 28.89		CXCR3_MOUSE (36-318): 4.07e-45: 160: 36.36
+	Hs
		150317 CXL11_HUMAN (1-94): 1.5e-27: 97.8: 100.00		CXCR3_HUMAN (36-312): 4.4e-42: 152: 35.36
+	Hs
		364105 CXL10_HUMAN (1-93): 5.22e-27: 96.3: 31.18		CXCR3_HUMAN (36-312): 4.4e-42: 152: 35.36
+	Hs
		486185 IL8_HUMAN (14-92): 3.1e-23: 87: 21.95		CXCR2_HUMAN (36-322): 2.86e-40: 147: 35.17
+	Hs
		486184 IL8_HUMAN (14-92): 3.1e-23: 87: 21.95		CXCR1_HUMAN (28-323): 4.1e-40: 146: 33.89
+	Hs
		587767 CXCL2_HUMAN (19-91): 1.84e-22: 85.1: 31.51		CXCR2_HUMAN (36-322): 2.86e-40: 147: 35.17
+	Hs
		830623 CXCL9_HUMAN (20-90): 3.13e-20: 80.1: 40.85		CXCR3_HUMAN (36-312): 4.4e-42: 152: 35.36
+	Hs
		625748 CXCL5_HUMAN (16-90): 1.53e-21: 83.2: 24.00		CXCR2_HUMAN (36-322): 2.86e-40: 147: 35.17
+	Hs
		625736 CXCL5_HUMAN (16-90): 1.53e-21: 83.2: 24.00		CXCR1_HUMAN (28-323): 4.1e-40: 146: 33.89
+	Hs
		364042 CXCL7_HUMAN (24-90): 5.74e-21: 82: 25.37		CXCR2_HUMAN (36-322): 2.86e-40: 147: 35.17
+	Hs
		448988 GROA_HUMAN (24-93): 3.65e-21: 82: 30.00		CXCR2_HUMAN (36-322): 2.86e-40: 147: 35.17
+	Hs
		587786 CXCL3_HUMAN (24-92): 5.01e-21: 81.6: 31.88		CXCR2_HUMAN (36-322): 2.86e-40: 147: 35.17
+	Hs
		364041 CXCL7_HUMAN (24-90): 5.74e-21: 82: 25.37		CXCR1_HUMAN (28-323): 4.1e-40: 146: 33.89
+	Hs
		448987 GROA_HUMAN (24-93): 3.65e-21: 82: 30.00		CXCR1_HUMAN (28-323): 4.1e-40: 146: 33.89
+	Hs
		625737 CXCL6_HUMAN (17-90): 2.68e-20: 79.7: 25.68		CXCR1_HUMAN (28-323): 4.1e-40: 146: 33.89