HitPredict

Interactor 1: DVL1 (O14640)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: SMAD7 (O15105)
Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)
Gene: SMAD7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12650946
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0008013 - beta-catenin binding GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0050821 - protein stabilization
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 695 Hs			1 426
+	Mm
		192484 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD7_MOUSE (1-426): 2.83e-174: 495: 98.12
+	Mm
		844410 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD1_MOUSE (79-424): 3.06e-145: 423: 24.71
+	Hs
		150693 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD3_HUMAN (81-424): 2.22e-146: 424: 26.72
+	Hs
		150710 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD1_HUMAN (79-424): 2.02e-145: 423: 24.26
+	Mm
		844423 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD2_MOUSE (82-424): 1.68e-138: 406: 24.53
+	Hs
		150709 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD2_HUMAN (82-424): 5.2e-138: 404: 24.53
+	Hs
		150947 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		SMAD3_HUMAN (81-424): 2.22e-146: 424: 26.72
+	Mm
		844412 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD4_MOUSE (54-259): 5.35e-42: 157: 22.38
+	Hs
		150701 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD4_HUMAN (54-259): 3.55e-41: 155: 22.75
+	Hs
		876396 AFAD_HUMAN (246-658): 1.91e-82: 288: 20.83		SMAD2_HUMAN (82-424): 5.2e-138: 404: 24.53
+	Hs
		1078635 NEB2_HUMAN (75-423): 2.81e-47: 181: 15.34		SMAD2_HUMAN (82-424): 5.2e-138: 404: 24.53
+	Hs
		1078579 RIMS1_HUMAN (8-675): 6.11e-45: 175: 14.18		SMAD2_HUMAN (82-424): 5.2e-138: 404: 24.53
+	Hs
		167376 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00
+	Hs
		950340 GRIP1_HUMAN (163-625): 8.94e-21: 99: 12.70		SMAD3_HUMAN (81-424): 2.22e-146: 424: 26.72
+	Hs
		950226 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD3_HUMAN (81-424): 2.22e-146: 424: 26.72
+	Hs
		1078732 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD1_HUMAN (79-424): 2.02e-145: 423: 24.26
+	Hs
		1078596 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD2_HUMAN (82-424): 5.2e-138: 404: 24.53
+	Hs
		1035517 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD4_HUMAN (54-259): 3.55e-41: 155: 22.75