HitPredict

Interactor 1: DVL1 (O14640)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: NCK2 (O43639)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	25416956
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0014069 - postsynaptic density GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 695 Hs			1 380
+	Hs
		209019 AFAD_HUMAN (246-658): 1.91e-82: 288: 20.83		NCK2_HUMAN (1-380): 6.88e-99: 300: 100.00
+	Mm
		403438 DVL2_MOUSE (3-695): 9.39e-142: 433: 56.39		SRC_MOUSE (6-153): 5.44e-20: 93.3: 17.33
+	Hs
		151007 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		ITSN1_HUMAN (6-70): 3.77e-19: 91.7: 29.23
+	Mm
		1141128 DVL2_MOUSE (3-695): 9.39e-142: 433: 56.39		GRB2_MOUSE (1-61): 1.04e-18: 85.9: 27.42
+	Hs
		150940 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81
+	Hs
		151122 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		SH3K1_HUMAN (8-109): 4.25e-16: 82: 16.35
+	Hs
		150821 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		YES_HUMAN (6-120): 7.99e-16: 80.8: 23.08
+	Mm
		223014 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		NCK2_MOUSE (1-380): 3.58e-98: 298: 96.05
+	Hs
		876349 AFAD_HUMAN (246-658): 1.91e-82: 288: 20.83		GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81
+	Hs
		522873 AFAD_HUMAN (246-658): 1.91e-82: 288: 20.83		SRC_HUMAN (203-361): 5.72e-16: 81.3: 31.55
+	Hs
		433300 AFAD_HUMAN (246-658): 1.91e-82: 288: 20.83		YES_HUMAN (6-120): 7.99e-16: 80.8: 23.08
+	Hs
		655344 DLG1_HUMAN (23-634): 4.33e-55: 205: 15.43		P85A_HUMAN (166-379): 4.05e-24: 106: 16.36
+	Hs
		412128 DLG4_HUMAN (104-626): 3.61e-56: 205: 17.42		FYN_HUMAN (7-137): 2.1e-23: 103: 20.30
+	Hs
		129286 DLG1_HUMAN (23-634): 4.33e-55: 205: 15.43		P85B_HUMAN (21-380): 7.78e-23: 102: 13.10
+	Mm
		411930 DLG1_MOUSE (23-634): 1.09e-58: 215: 15.72		LCK_MOUSE (3-188): 2.6e-19: 91.4: 16.58
+	Mm
		403445 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		SRC_MOUSE (6-153): 5.44e-20: 93.3: 17.33
+	Hs
		411698 DLG1_HUMAN (23-634): 4.33e-55: 205: 15.43		LCK_HUMAN (3-145): 6.3e-19: 90.2: 21.53
+	Mm
		1141133 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		GRB2_MOUSE (1-61): 1.04e-18: 85.9: 27.42
+	Mm
		1143451 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		SH3K1_MOUSE (8-109): 3.82e-16: 82: 17.31
+	Hs
		924466 DLG4_HUMAN (104-626): 3.61e-56: 205: 17.42		GRB2_HUMAN (3-61): 2.24e-18: 84.7: 28.81