HitPredict

Interactor 1: DVL1 (O14640)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	22467858
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007528 - neuromuscular junction development GO:0019899 - enzyme binding GO:0043197 - dendritic spine
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 695 Hs			1 1319
+	Hs
		151146 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		150723 DVL1_HUMAN (1-695): 0: 550: 100.00		HECW1_HUMAN (475-1317): 0: 726: 31.48
+	Mm
		1143429 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		NED4L_MOUSE (517-1319): 0: 936: 62.42
+	Mm
		93273 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		E9PXB7_MOUSE (539-1319): 0: 907: 62.80
+	Hs
		150725 DVL1_HUMAN (1-695): 0: 550: 100.00		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Hs
		1192152 DVL3_HUMAN (1-695): 1.01e-153: 463: 61.00		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Hs
		150752 DVL1_HUMAN (1-695): 0: 550: 100.00		WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86
+	Hs
		124995 DVL1_HUMAN (1-695): 0: 550: 100.00		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Hs
		150747 DVL1_HUMAN (1-695): 0: 550: 100.00		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42
+	Mm
		56824 DVL1_MOUSE (1-695): 0: 559: 94.83		SMUF2_MOUSE (454-719): 9.32e-26: 116: 17.86
+	Hs
		1273633 DVL3_HUMAN (1-695): 1.01e-153: 463: 61.00		WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86
+	Hs
		151182 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86
+	Hs
		124996 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Hs
		1273604 DVL3_HUMAN (1-695): 1.01e-153: 463: 61.00		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42
+	Hs
		151140 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42
+	Mm
		56830 DVL2_MOUSE (3-695): 9.39e-142: 433: 56.39		SMUF2_MOUSE (454-719): 9.32e-26: 116: 17.86
+	Hs
		151200 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86
+	Mm
		1141509 DVL2_MOUSE (3-695): 9.39e-142: 433: 56.39		SMUF1_MOUSE (539-719): 1.75e-21: 103: 18.65
+	Hs
		151206 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82
+	Ce
		1094742 MIG5_CAEEL (2-501): 2.28e-67: 235: 27.31		Q9BKW4_CAEEL (716-837): 5.65e-13: 75.2: 13.93