HitPredict

Interactor 1: DVL1 (O14640)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 695 Hs			1 603
+	Hs
		861877 DVL3_HUMAN (1-695): 1.01e-153: 463: 61.00		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Hs
		150919 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Hs
		150707 DVL1_HUMAN (1-695): 0: 550: 100.00		KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43
+	Ce
		711481 Q18239_CAEEL (4-643): 4.95e-84: 282: 28.78		PLK1_CAEEL (22-599): 0: 536: 50.58
+	Hs
		861765 DIXC1_HUMAN (4-81): 3.14e-26: 116: 42.31		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Hs
		861861 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Ce
		1093973 MIG5_CAEEL (2-501): 2.28e-67: 235: 27.31		PLK3_CAEEL (23-591): 4.14e-157: 465: 39.14
+	Hs
		150772 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17
+	Mm
		1143553 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		KS6A2_MOUSE (1-367): 4.69e-110: 348: 23.48
+	Hs
		942348 DLG4_HUMAN (104-626): 3.61e-56: 205: 17.42		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Hs
		1021498 DLG1_HUMAN (23-634): 4.33e-55: 205: 15.43		KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43
+	Hs
		1071685 NEB2_HUMAN (75-423): 2.81e-47: 181: 15.34		KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43
+	Hs
		883917 SYJ2B_HUMAN (249-324): 1.27e-15: 76.5: 35.00		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Hs
		1073470 MAGI1_HUMAN (118-687): 3.03e-12: 72.2: 11.70		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Ce
		86411 C1P635_CAEEL (142-321): 8.21e-14: 77.4: 19.79		AIR2_CAEEL (35-314): 4.72e-41: 152: 32.06