HitPredict

Interactor 1: DVL1 (O14640)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: SMAD1 (Q15797)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
Gene: SMAD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12650946
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 695 Hs			1 465
+	Mm
		844410 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD1_MOUSE (1-465): 0: 656: 99.14
+	Hs
		150693 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD3_HUMAN (3-465): 0: 556: 59.66
+	Mm
		844423 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD2_MOUSE (3-465): 0: 543: 55.14
+	Hs
		150709 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD2_HUMAN (3-465): 0: 541: 55.14
+	Mm
		844412 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD4_MOUSE (13-454): 7.4e-151: 442: 34.66
+	Hs
		150701 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD4_HUMAN (13-454): 1.6e-150: 441: 34.28
+	Hs
		150947 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		SMAD3_HUMAN (3-465): 0: 556: 59.66
+	Hs
		876396 AFAD_HUMAN (246-658): 1.91e-82: 288: 20.83		SMAD2_HUMAN (3-465): 0: 541: 55.14
+	Hs
		1078732 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD1_HUMAN (1-465): 0: 658: 100.00
+	Hs
		1078635 NEB2_HUMAN (75-423): 2.81e-47: 181: 15.34		SMAD2_HUMAN (3-465): 0: 541: 55.14
+	Hs
		1078579 RIMS1_HUMAN (8-675): 6.11e-45: 175: 14.18		SMAD2_HUMAN (3-465): 0: 541: 55.14
+	Mm
		192484 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD7_MOUSE (30-131): 1.05e-24: 107: 33.33
+	Hs
		150650 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD7_HUMAN (30-131): 2.89e-25: 109: 32.46
+	Hs
		950340 GRIP1_HUMAN (163-625): 8.94e-21: 99: 12.70		SMAD3_HUMAN (3-465): 0: 556: 59.66
+	Hs
		950226 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD3_HUMAN (3-465): 0: 556: 59.66
+	Hs
		1078596 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD2_HUMAN (3-465): 0: 541: 55.14
+	Hs
		1035517 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD4_HUMAN (13-454): 1.6e-150: 441: 34.28
+	Hs
		167376 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD7_HUMAN (30-131): 2.89e-25: 109: 32.46