HitPredict

Interactor 1: DVL1 (O14640)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: KLH12 (Q53G59)
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
Gene: KLHL12

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.629

Property	Details
Experiments	32296183, 32574548
Identification Methods	two hybrid, unspecified method, x-ray crystallography, affinity chromatography technology
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 695 Hs			1 568
+	Hs
		1120796 DVL3_HUMAN (1-695): 1.01e-153: 463: 61.00		KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00
+	Hs
		151017 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00
+	Dm
		844391 DSH_DROME (2-547): 2.69e-107: 340: 44.84		KLHDB_DROME (3-566): 3.83e-171: 500: 42.23
+	Dm
		844344 DSH_DROME (2-547): 2.69e-107: 340: 44.84		KELC_DROME (9-567): 1.41e-157: 489: 40.04
+	Ce
		105852 H2KZ17_CAEEL (4-552): 6.19e-89: 294: 37.16		KLHL8_CAEEL (2-563): 7.57e-143: 430: 28.89
+	Rn
		677801 DLG4_RAT (104-626): 1.68e-56: 207: 17.60		KLH17_RAT (11-566): 1.56e-162: 479: 40.75
+	Hs
		1120779 Q86TH3_HUMAN (1-226): 2.72e-42: 161: 96.46		KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00
+	Ce
		69953 B1Q240_CAEEL (79-554): 4.07e-61: 222: 35.01		KLHL8_CAEEL (2-563): 7.57e-143: 430: 28.89