HitPredict

Interactor 1: DVL1 (O14640)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: HECW1 (Q76N89)
E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)
Gene: HECW1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	14684739
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 695 Hs			1 1606
+	Hs
		150747 DVL1_HUMAN (1-695): 0: 550: 100.00		ITCH_HUMAN (865-1606): 0: 695: 30.78
+	Mm
		56824 DVL1_MOUSE (1-695): 0: 559: 94.83		SMUF2_MOUSE (1017-1606): 0: 648: 35.67
+	Hs
		150684 DVL1_HUMAN (1-695): 0: 550: 100.00		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		1273604 DVL3_HUMAN (1-695): 1.01e-153: 463: 61.00		ITCH_HUMAN (865-1606): 0: 695: 30.78
+	Hs
		151140 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		ITCH_HUMAN (865-1606): 0: 695: 30.78
+	Mm
		56830 DVL2_MOUSE (3-695): 9.39e-142: 433: 56.39		SMUF2_MOUSE (1017-1606): 0: 648: 35.67
+	Hs
		151200 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		SMUF2_HUMAN (1017-1606): 0: 646: 35.34
+	Mm
		1141509 DVL2_MOUSE (3-695): 9.39e-142: 433: 56.39		SMUF1_MOUSE (1034-1606): 0: 624: 35.64
+	Hs
		151206 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		SMUF1_HUMAN (1034-1606): 0: 611: 33.82
+	Ce
		1094742 MIG5_CAEEL (2-501): 2.28e-67: 235: 27.31		Q9BKW4_CAEEL (1130-1604): 0: 612: 40.50
+	Hs
		124995 DVL1_HUMAN (1-695): 0: 550: 100.00		WWP2_HUMAN (630-993): 7.45e-23: 108: 17.32
+	Hs
		150752 DVL1_HUMAN (1-695): 0: 550: 100.00		WWP1_HUMAN (599-984): 4.59e-19: 96: 16.58
+	Hs
		150725 DVL1_HUMAN (1-695): 0: 550: 100.00		HUWE1_HUMAN (443-917): 1.91e-09: 65.1: 9.71
+	Hs
		1273633 DVL3_HUMAN (1-695): 1.01e-153: 463: 61.00		WWP1_HUMAN (599-984): 4.59e-19: 96: 16.58
+	Hs
		124996 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		WWP2_HUMAN (630-993): 7.45e-23: 108: 17.32
+	Hs
		1192152 DVL3_HUMAN (1-695): 1.01e-153: 463: 61.00		HUWE1_HUMAN (443-917): 1.91e-09: 65.1: 9.71
+	Hs
		151182 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		WWP1_HUMAN (599-984): 4.59e-19: 96: 16.58
+	Hs
		151146 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		NED4L_HUMAN (687-1062): 2.52e-15: 84.1: 15.96
+	Mm
		1143429 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		NED4L_MOUSE (686-1055): 9.1e-16: 85.6: 17.03
+	Mm
		93273 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		E9PXB7_MOUSE (760-1062): 1.36e-13: 78.3: 17.82