HitPredict

Interactor 1: DVL1 (O14640)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22826439
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0031410 - cytoplasmic vesicle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 695 Hs			1 903
+	Hs
		1273604 DVL3_HUMAN (1-695): 1.01e-153: 463: 61.00		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		150752 DVL1_HUMAN (1-695): 0: 550: 100.00		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		124995 DVL1_HUMAN (1-695): 0: 550: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		151140 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		1273633 DVL3_HUMAN (1-695): 1.01e-153: 463: 61.00		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		151182 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		124996 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		150684 DVL1_HUMAN (1-695): 0: 550: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		151146 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		150725 DVL1_HUMAN (1-695): 0: 550: 100.00		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		1192152 DVL3_HUMAN (1-695): 1.01e-153: 463: 61.00		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Mm
		1143429 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		NED4L_MOUSE (2-900): 0: 765: 32.32
+	Mm
		93273 DLG4_MOUSE (104-626): 5.62e-57: 208: 17.60		E9PXB7_MOUSE (86-900): 0: 654: 34.22
+	Mm
		56824 DVL1_MOUSE (1-695): 0: 559: 94.83		SMUF2_MOUSE (1-358): 2.99e-46: 179: 16.67
+	Hs
		150723 DVL1_HUMAN (1-695): 0: 550: 100.00		HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76
+	Hs
		151206 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Mm
		56830 DVL2_MOUSE (3-695): 9.39e-142: 433: 56.39		SMUF2_MOUSE (1-358): 2.99e-46: 179: 16.67
+	Hs
		151200 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94
+	Mm
		1141509 DVL2_MOUSE (3-695): 9.39e-142: 433: 56.39		SMUF1_MOUSE (1-535): 3.62e-41: 164: 14.07
+	Ce
		1094742 MIG5_CAEEL (2-501): 2.28e-67: 235: 27.31		Q9BKW4_CAEEL (319-581): 6.75e-13: 74.2: 16.33