HitPredict

Interactor 1: DVL1 (O14640)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.612

Property	Details
Experiments	20412773, 38280479
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001933 - negative regulation of protein phosphorylation GO:0005829 - cytosol GO:0006355 - regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 695 Hs			1 400
+	Hs
		1273630 DVL3_HUMAN (1-695): 1.01e-153: 463: 61.00		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Hs
		151179 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Hs
		150752 DVL1_HUMAN (1-695): 0: 550: 100.00		WWP1_HUMAN (3-386): 5.05e-64: 222: 13.86
+	Hs
		150747 DVL1_HUMAN (1-695): 0: 550: 100.00		ITCH_HUMAN (37-356): 2.6e-60: 211: 14.83
+	Hs
		124995 DVL1_HUMAN (1-695): 0: 550: 100.00		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		150723 DVL1_HUMAN (1-695): 0: 550: 100.00		HECW1_HUMAN (14-327): 1.21e-53: 194: 14.29
+	Hs
		1273633 DVL3_HUMAN (1-695): 1.01e-153: 463: 61.00		WWP1_HUMAN (3-386): 5.05e-64: 222: 13.86
+	Hs
		1273604 DVL3_HUMAN (1-695): 1.01e-153: 463: 61.00		ITCH_HUMAN (37-356): 2.6e-60: 211: 14.83
+	Mm
		56824 DVL1_MOUSE (1-695): 0: 559: 94.83		SMUF2_MOUSE (156-326): 1.17e-24: 108: 11.40
+	Hs
		150684 DVL1_HUMAN (1-695): 0: 550: 100.00		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Hs
		151182 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		WWP1_HUMAN (3-386): 5.05e-64: 222: 13.86
+	Hs
		151140 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		ITCH_HUMAN (37-356): 2.6e-60: 211: 14.83
+	Hs
		150757 DVL1_HUMAN (1-695): 0: 550: 100.00		WWOX_HUMAN (111-236): 1.79e-18: 88.4: 21.09
+	Hs
		124996 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Mm
		1141509 DVL2_MOUSE (3-695): 9.39e-142: 433: 56.39		SMUF1_MOUSE (81-321): 4.85e-51: 184: 18.70
+	Hs
		151206 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62
+	Hs
		1273659 DVL3_HUMAN (1-695): 1.01e-153: 463: 61.00		WWOX_HUMAN (111-236): 1.79e-18: 88.4: 21.09
+	Mm
		56830 DVL2_MOUSE (3-695): 9.39e-142: 433: 56.39		SMUF2_MOUSE (156-326): 1.17e-24: 108: 11.40
+	Hs
		151200 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		SMUF2_HUMAN (156-326): 4.16e-25: 109: 11.92
+	Hs
		151146 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		NED4L_HUMAN (164-352): 3.03e-13: 73.5: 13.20