HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	21516116
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 543
+	Mm
		403438 DVL2_MOUSE (13-736): 0: 550: 96.69		SRC_MOUSE (1-543): 0: 598: 73.67
+	Mm
		435884 DVL2_MOUSE (13-736): 0: 550: 96.69		HCK_MOUSE (1-541): 0: 529: 56.93
+	Hs
		150822 DVL2_HUMAN (1-736): 0: 547: 100.00		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69
+	Hs
		150807 DVL2_HUMAN (1-736): 0: 547: 100.00		ABL1_HUMAN (41-543): 5.93e-161: 489: 39.10
+	Dm
		337649 DSH_DROME (9-563): 1.78e-121: 379: 46.29		ABL_DROME (82-543): 1.38e-159: 496: 42.22
+	Mm
		403445 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		SRC_MOUSE (1-543): 0: 598: 73.67
+	Hs
		412128 DLG4_HUMAN (108-707): 2.94e-75: 259: 15.53		FYN_HUMAN (1-543): 0: 582: 72.16
+	Mm
		411930 DLG1_MOUSE (94-707): 3.76e-84: 287: 15.74		LCK_MOUSE (83-541): 0: 542: 60.78
+	Hs
		411698 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		LCK_HUMAN (83-541): 0: 540: 60.78
+	Hs
		433300 AFAD_HUMAN (256-701): 1.96e-50: 193: 20.93		YES_HUMAN (1-543): 0: 617: 100.00
+	Hs
		433731 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69
+	Ce
		106665 Q18239_CAEEL (14-643): 2.24e-91: 303: 28.83		SRC1_CAEEL (1-541): 2.11e-169: 492: 47.02
+	Hs
		522873 AFAD_HUMAN (256-701): 1.96e-50: 193: 20.93		SRC_HUMAN (1-543): 0: 601: 74.22
+	Ce
		371320 MIG5_CAEEL (12-558): 2.34e-78: 266: 25.85		ABL1_CAEEL (4-534): 6.48e-165: 502: 37.41
+	Hs
		412246 RIMS1_HUMAN (92-722): 9.64e-47: 181: 14.15		FYN_HUMAN (1-543): 0: 582: 72.16
+	Hs
		872639 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		EPHA4_HUMAN (4-542): 2.62e-155: 470: 25.00
+	Hs
		433666 AFAD_HUMAN (256-701): 1.96e-50: 193: 20.93		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69
+	Hs
		434073 NEB1_HUMAN (93-347): 2.94e-43: 171: 17.58		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69
+	Hs
		337498 RIMS1_HUMAN (92-722): 9.64e-47: 181: 14.15		ABL1_HUMAN (41-543): 5.93e-161: 489: 39.10
+	Hs
		411696 PTN13_HUMAN (97-531): 5.7e-17: 88: 15.40		LCK_HUMAN (83-541): 0: 540: 60.78