HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.50	0.470

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 806
+	Hs
		150889 DVL2_HUMAN (1-736): 0: 547: 100.00		FLT3_HUMAN (11-791): 1.67e-162: 499: 23.74
+	Hs
		150814 DVL2_HUMAN (1-736): 0: 547: 100.00		NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02
+	Mm
		546286 DVL1_MOUSE (11-736): 5.49e-170: 506: 57.32		NTRK2_MOUSE (158-756): 2.71e-161: 490: 25.19
+	Mm
		546299 DVL3_MOUSE (11-736): 4.73e-159: 479: 65.18		NTRK2_MOUSE (158-756): 2.71e-161: 490: 25.19
+	Hs
		385298 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02
+	Hs
		1021499 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		EPHA7_HUMAN (1-782): 0: 626: 21.22
+	Hs
		872433 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		EPHA5_HUMAN (1-777): 0: 622: 20.18
+	Hs
		872639 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		EPHA4_HUMAN (1-781): 0: 622: 20.78
+	Hs
		876391 AFAD_HUMAN (256-701): 1.96e-50: 193: 20.93		EPHA7_HUMAN (1-782): 0: 626: 21.22
+	Hs
		665569 AFAD_HUMAN (256-701): 1.96e-50: 193: 20.93		EPHB2_HUMAN (1-788): 0: 624: 19.15
+	Hs
		872454 RIMS1_HUMAN (92-722): 9.64e-47: 181: 14.15		EPHA5_HUMAN (1-777): 0: 622: 20.18
+	Hs
		1021503 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		NTRK3_HUMAN (130-757): 4.66e-167: 506: 24.59
+	Hs
		665186 AFAD_HUMAN (256-701): 1.96e-50: 193: 20.93		EPHA2_HUMAN (1-788): 0: 595: 21.50
+	Hs
		872402 AFAD_HUMAN (256-701): 1.96e-50: 193: 20.93		EPHB3_HUMAN (1-786): 0: 585: 18.66
+	Hs
		942352 DLG4_HUMAN (108-707): 2.94e-75: 259: 15.53		NTRK2_HUMAN (159-756): 1.53e-161: 491: 25.51
+	Mm
		546303 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		NTRK2_MOUSE (158-756): 2.71e-161: 490: 25.19
+	Hs
		384746 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02
+	Mm
		546326 AFAD_MOUSE (256-702): 1.28e-45: 178: 19.48		NTRK2_MOUSE (158-756): 2.71e-161: 490: 25.19
+	Hs
		384568 AFAD_HUMAN (256-701): 1.96e-50: 193: 20.93		NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02
+	Mm
		844421 DVL1_MOUSE (11-736): 5.49e-170: 506: 57.32		MUSK_MOUSE (40-466): 2.1e-29: 127: 18.06