HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: APC (P25054)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Gene: APC

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26496610, 20224554
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016328 - lateral plasma membrane and 1 others more... GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 2843
+	Hs
		150673 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		APC_HUMAN (1-2843): 0: 1316: 100.00
+	Hs
		626082 DVLP1_HUMAN (11-736): 6.54e-163: 487: 56.44		APC_HUMAN (1-2843): 0: 1316: 100.00
+	Mm
		1141494 DVL2_MOUSE (13-736): 0: 550: 96.69		APC_MOUSE (1-2843): 0: 1220: 89.82
+	Hs
		626115 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		APC_HUMAN (1-2843): 0: 1316: 100.00
+	Hs
		626216 DLG3_HUMAN (80-706): 1.51e-73: 256: 14.93		APC_HUMAN (1-2843): 0: 1316: 100.00
+	Hs
		626083 AFAD_HUMAN (256-701): 1.96e-50: 193: 20.93		APC_HUMAN (1-2843): 0: 1316: 100.00
+	Rn
		677772 DLG4_RAT (108-707): 4.11e-75: 258: 15.53		APC_RAT (1-2843): 0: 1222: 89.60
+	Mm
		1142526 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		APC_MOUSE (1-2843): 0: 1220: 89.82
+	Hs
		151109 DVL2_HUMAN (1-736): 0: 547: 100.00		TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55
+	Ce
		1094130 MIG5_CAEEL (12-558): 2.34e-78: 266: 25.85		APR1_CAEEL (274-1464): 5.62e-115: 399: 16.91
+	Hs
		944673 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		MAP1A_HUMAN (907-2836): 5.17e-16: 87.6: 8.68
+	Rn
		713905 DLG1_RAT (94-707): 2.78e-80: 277: 15.12		MAP1A_RAT (823-2474): 2.27e-13: 78.8: 8.11
+	Mm
		1143541 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		MAP1A_MOUSE (738-2466): 8.19e-18: 93.6: 8.21
+	Hs
		942322 DLG4_HUMAN (108-707): 2.94e-75: 259: 15.53		MAP1A_HUMAN (907-2836): 5.17e-16: 87.6: 8.68
+	Mm
		1143421 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		ANK2_MOUSE (1056-2841): 1.1e-15: 86.5: 9.74
+	Rn
		677763 DLG4_RAT (108-707): 4.11e-75: 258: 15.53		MAP1A_RAT (823-2474): 2.27e-13: 78.8: 8.11
+	Rn
		713908 DLG2_RAT (93-707): 5.92e-71: 250: 12.83		MAP1A_RAT (823-2474): 2.27e-13: 78.8: 8.11
+	Hs
		876457 AFAD_HUMAN (256-701): 1.96e-50: 193: 20.93		TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55
+	Hs
		944681 DLG2_HUMAN (92-707): 2.88e-61: 223: 13.85		MAP1A_HUMAN (907-2836): 5.17e-16: 87.6: 8.68
+	Hs
		297818 AFAD_HUMAN (256-701): 1.96e-50: 193: 20.93		K0754_HUMAN (1032-1505): 1.35e-11: 73.3: 13.47