HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	25659891, 32707033, 31340145, 36398662, 22609948
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 736 Hs			1 603
+	Hs
		150689 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Hs
		861877 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Ce
		711481 Q18239_CAEEL (14-643): 2.24e-91: 303: 28.83		PLK1_CAEEL (22-599): 0: 536: 50.58
+	Hs
		150707 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43
+	Hs
		861765 DIXC1_HUMAN (14-89): 2.09e-29: 126: 43.42		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Ce
		1093973 MIG5_CAEEL (12-558): 2.34e-78: 266: 25.85		PLK3_CAEEL (23-591): 4.14e-157: 465: 39.14
+	Hs
		150772 DVL2_HUMAN (1-736): 0: 547: 100.00		AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17
+	Hs
		1021498 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43
+	Mm
		1143553 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		KS6A2_MOUSE (1-367): 4.69e-110: 348: 23.48
+	Hs
		942348 DLG4_HUMAN (108-707): 2.94e-75: 259: 15.53		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Hs
		1073494 NEB1_HUMAN (93-347): 2.94e-43: 171: 17.58		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Hs
		1073434 MAGI3_HUMAN (223-577): 5.73e-16: 84.5: 11.78		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Hs
		883917 SYJ2B_HUMAN (258-341): 2.66e-16: 78.4: 30.68		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Ce
		86411 C1P635_CAEEL (134-337): 7.77e-14: 77.4: 17.79		AIR2_CAEEL (35-314): 4.72e-41: 152: 32.06