HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: KLH12 (Q53G59)
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
Gene: KLHL12

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	27107012, 35509083
Identification Methods	two hybrid, affinity chromatography technology, barcode fusion genetics two hybrid, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 736 Hs			1 568
+	Hs
		150714 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00
+	Hs
		1120796 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00
+	Dm
		844391 DSH_DROME (9-563): 1.78e-121: 379: 46.29		KLHDB_DROME (3-566): 3.83e-171: 500: 42.23
+	Dm
		844344 DSH_DROME (9-563): 1.78e-121: 379: 46.29		KELC_DROME (9-567): 1.41e-157: 489: 40.04
+	Ce
		105852 H2KZ17_CAEEL (14-602): 9.48e-103: 332: 34.98		KLHL8_CAEEL (2-563): 7.57e-143: 430: 28.89
+	Rn
		677801 DLG4_RAT (108-707): 4.11e-75: 258: 15.53		KLH17_RAT (11-566): 1.56e-162: 479: 40.75
+	Hs
		1120779 Q86TH3_HUMAN (473-736): 4.98e-56: 199: 47.55		KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00
+	Ce
		69953 B1Q240_CAEEL (65-548): 1.62e-57: 212: 34.93		KLHL8_CAEEL (2-563): 7.57e-143: 430: 28.89