HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: RB6I2 (Q8IUD2)
ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2)
Gene: ERC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26496610, 34299191
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0006355 - regulation of DNA-templated transcription GO:0031267 - small GTPase binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 736 Hs			1 1116
+	Hs
		150837 DVL2_HUMAN (1-736): 0: 547: 100.00		MYH7_HUMAN (6-513): 7.72e-21: 101: 9.84
+	Hs
		150999 DVL2_HUMAN (1-736): 0: 547: 100.00		EEA1_HUMAN (557-1116): 4.52e-19: 95.6: 12.23
+	Hs
		150964 DVL2_HUMAN (1-736): 0: 547: 100.00		CGNL1_HUMAN (404-989): 2.32e-10: 67.4: 20.85
+	Hs
		1067454 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		EEA1_HUMAN (557-1116): 4.52e-19: 95.6: 12.23
+	Hs
		1199973 RIMS1_HUMAN (92-722): 9.64e-47: 181: 14.15		RB6I2_HUMAN (1-1116): 2.23e-82: 293: 100.00
+	Mm
		823534 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		CTRO_MOUSE (138-731): 1e-19: 98.2: 16.37
+	Rn
		92840 DLG4_RAT (108-707): 4.11e-75: 258: 15.53		CTRO_RAT (152-731): 4.63e-17: 89.3: 14.72
+	Hs
		724903 RIMS1_HUMAN (92-722): 9.64e-47: 181: 14.15		MYH9_HUMAN (2-736): 1.6e-33: 142: 9.92
+	Mm
		936586 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		ROCK2_MOUSE (162-847): 3.98e-09: 63.2: 20.90
+	Hs
		166838 RIMS1_HUMAN (92-722): 9.64e-47: 181: 14.15		ERC2_HUMAN (283-1051): 5.93e-28: 124: 13.05
+	Hs
		725194 RIMS1_HUMAN (92-722): 9.64e-47: 181: 14.15		MYH10_HUMAN (664-1113): 2.61e-18: 93.3: 12.09
+	Hs
		724845 DIXC1_HUMAN (14-89): 2.09e-29: 126: 43.42		MYH9_HUMAN (2-736): 1.6e-33: 142: 9.92
+	Hs
		876370 AFAD_HUMAN (256-701): 1.96e-50: 193: 20.93		CGNL1_HUMAN (404-989): 2.32e-10: 67.4: 20.85
+	Hs
		148925 MAGI3_HUMAN (223-577): 5.73e-16: 84.5: 11.78		CTRO_HUMAN (156-792): 2.47e-18: 93.5: 12.63
+	Hs
		149079 INADL_HUMAN (243-345): 1.2e-12: 73.8: 26.85		CTRO_HUMAN (156-792): 2.47e-18: 93.5: 12.63
+	Ce
		88184 D3YT29_CAEEL (241-357): 7.27e-13: 74.3: 30.77		O44490_CAEEL (161-834): 3.6e-09: 63.2: 20.15