HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: VANG1 (Q8TAA9)
Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1)
Gene: VANGL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	31340145, 33961781, 36398662
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016328 - lateral plasma membrane GO:0060071 - Wnt signaling pathway, planar cell polarity pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 524
+	Mm
		1141500 DVL2_MOUSE (13-736): 0: 550: 96.69		VANG1_MOUSE (1-524): 0: 805: 95.06
+	Mm
		844428 DVL1_MOUSE (11-736): 5.49e-170: 506: 57.32		VANG1_MOUSE (1-524): 0: 805: 95.06
+	Hs
		1250791 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		VANG1_HUMAN (1-524): 0: 822: 100.00
+	Mm
		1142090 DVL3_MOUSE (11-736): 4.73e-159: 479: 65.18		VANG1_MOUSE (1-524): 0: 805: 95.06
+	Mm
		1141507 DVL2_MOUSE (13-736): 0: 550: 96.69		VANG2_MOUSE (1-524): 0: 671: 71.86
+	Hs
		151251 DVL2_HUMAN (1-736): 0: 547: 100.00		VANG2_HUMAN (1-524): 0: 668: 72.05
+	Mm
		844432 DVL1_MOUSE (11-736): 5.49e-170: 506: 57.32		VANG2_MOUSE (1-524): 0: 671: 71.86
+	Mm
		1142094 DVL3_MOUSE (11-736): 4.73e-159: 479: 65.18		VANG2_MOUSE (1-524): 0: 671: 71.86
+	Hs
		1273675 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		VANG2_HUMAN (1-524): 0: 668: 72.05
+	Hs
		1021536 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		VANG1_HUMAN (1-524): 0: 822: 100.00
+	Dm
		219854 DSH_DROME (9-563): 1.78e-121: 379: 46.29		O45030_DROME (21-524): 0: 689: 45.02
+	Dm
		52640 DSH_DROME (9-563): 1.78e-121: 379: 46.29		A1Z7N9_DROME (21-524): 0: 689: 45.02
+	Mm
		1143382 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		VANG1_MOUSE (1-524): 0: 805: 95.06
+	Hs
		876447 AFAD_HUMAN (256-701): 1.96e-50: 193: 20.93		VANG1_HUMAN (1-524): 0: 822: 100.00
+	Ce
		109389 Q18239_CAEEL (14-643): 2.24e-91: 303: 28.83		H2KY90_CAEEL (2-524): 0: 674: 32.97
+	Hs
		1021588 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		VANG2_HUMAN (1-524): 0: 668: 72.05
+	Mm
		1143470 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		VANG2_MOUSE (1-524): 0: 671: 71.86
+	Rn
		677774 DLG4_RAT (108-707): 4.11e-75: 258: 15.53		VANG2_RAT (1-524): 0: 671: 71.86
+	Dm
		219853 DLG1_DROME (13-707): 2.23e-52: 198: 14.00		O45030_DROME (21-524): 0: 689: 45.02
+	Dm
		52639 DLG1_DROME (13-707): 2.23e-52: 198: 14.00		A1Z7N9_DROME (21-524): 0: 689: 45.02