HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: AP2M1 (Q96CW1)
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: AP2M1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.885

Property	Details
Experiments	16189514, 31340145, 36398662, 31515488
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Adap_comp_sub~DEP
Common GO terms	GO:0005829 - cytosol GO:0031410 - cytoplasmic vesicle GO:0045334 - clathrin-coated endocytic vesicle
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 736 Hs			1 435
+	Hs
		151169 DVL2_HUMAN (1-736): 0: 547: 100.00		AP1M1_HUMAN (2-434): 5.69e-170: 484: 38.85
+	Hs
		1273682 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		AP3M1_HUMAN (1-434): 1.4e-123: 366: 24.66
+	Hs
		151107 DVL2_HUMAN (1-736): 0: 547: 100.00		STON2_HUMAN (146-433): 1.58e-62: 219: 22.85
+	Ce
		725354 MIG5_CAEEL (12-558): 2.34e-78: 266: 25.85		AP1M_CAEEL (3-434): 9.63e-161: 461: 39.86
+	Hs
		1199986 RIMS1_HUMAN (92-722): 9.64e-47: 181: 14.15		AP2M1_HUMAN (1-435): 1.03e-178: 507: 100.00