HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	31340145, 36398662
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 975
+	Hs
		151182 DVL2_HUMAN (1-736): 0: 547: 100.00		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		151140 DVL2_HUMAN (1-736): 0: 547: 100.00		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		150752 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		124996 DVL2_HUMAN (1-736): 0: 547: 100.00		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		1273633 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		150747 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		1273604 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		150684 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		124995 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Mm
		93273 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		E9PXB7_MOUSE (122-975): 0: 863: 95.79
+	Hs
		150725 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		1192152 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Ce
		1094742 MIG5_CAEEL (12-558): 2.34e-78: 266: 25.85		Q9BKW4_CAEEL (492-975): 0: 662: 60.74
+	Hs
		1021523 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Hs
		151206 DVL2_HUMAN (1-736): 0: 547: 100.00		SMUF1_HUMAN (17-499): 1.65e-30: 131: 15.71
+	Mm
		56830 DVL2_MOUSE (13-736): 0: 550: 96.69		SMUF2_MOUSE (21-324): 1.92e-29: 128: 22.56
+	Mm
		1141509 DVL2_MOUSE (13-736): 0: 550: 96.69		SMUF1_MOUSE (17-365): 1.1e-28: 125: 17.37
+	Hs
		151200 DVL2_HUMAN (1-736): 0: 547: 100.00		SMUF2_HUMAN (21-324): 2e-29: 127: 22.56
+	Mm
		56824 DVL1_MOUSE (11-736): 5.49e-170: 506: 57.32		SMUF2_MOUSE (21-324): 1.92e-29: 128: 22.56
+	Hs
		150723 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		HECW1_HUMAN (144-528): 1.92e-09: 64.2: 13.73