HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19379695
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0060071 - Wnt signaling pathway, planar cell polarity pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 757
+	Mm
		1141509 DVL2_MOUSE (13-736): 0: 550: 96.69		SMUF1_MOUSE (1-757): 0: 855: 95.24
+	Mm
		56830 DVL2_MOUSE (13-736): 0: 550: 96.69		SMUF2_MOUSE (1-757): 0: 795: 71.30
+	Hs
		151200 DVL2_HUMAN (1-736): 0: 547: 100.00		SMUF2_HUMAN (1-757): 0: 794: 70.72
+	Mm
		56824 DVL1_MOUSE (11-736): 5.49e-170: 506: 57.32		SMUF2_MOUSE (1-757): 0: 795: 71.30
+	Hs
		151140 DVL2_HUMAN (1-736): 0: 547: 100.00		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		124996 DVL2_HUMAN (1-736): 0: 547: 100.00		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		150747 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		1273604 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		124995 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		150684 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		150725 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		HUWE1_HUMAN (71-756): 0: 583: 30.14
+	Hs
		1192152 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		HUWE1_HUMAN (71-756): 0: 583: 30.14
+	Mm
		93273 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		E9PXB7_MOUSE (153-755): 0: 633: 40.69
+	Ce
		1094742 MIG5_CAEEL (12-558): 2.34e-78: 266: 25.85		Q9BKW4_CAEEL (229-755): 0: 612: 42.34
+	Hs
		1021523 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		HUWE1_HUMAN (71-756): 0: 583: 30.14
+	Hs
		151146 DVL2_HUMAN (1-736): 0: 547: 100.00		NED4L_HUMAN (6-396): 7.88e-36: 147: 16.88
+	Hs
		151182 DVL2_HUMAN (1-736): 0: 547: 100.00		WWP1_HUMAN (2-395): 1.65e-27: 121: 14.94
+	Hs
		150752 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		WWP1_HUMAN (2-395): 1.65e-27: 121: 14.94
+	Hs
		1273633 DVL3_HUMAN (11-736): 4.58e-160: 482: 65.04		WWP1_HUMAN (2-395): 1.65e-27: 121: 14.94
+	Hs
		150723 DVL1_HUMAN (11-736): 7.51e-163: 488: 57.32		HECW1_HUMAN (2-213): 2.55e-19: 95.6: 15.28