HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: DACT1 (Q9NYF0)
Dapper homolog 1 (hDPR1) (Dapper antagonist of catenin 1) (Hepatocellular carcinoma novel gene 3 protein)
Gene: DACT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	25558878, 21262972, 16446366
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 836
+	Xl
		844441 DVL2_XENLA (11-736): 4.16e-163: 490: 71.95		DCT1B_XENLA (11-836): 0: 798: 59.62
+	Rn
		88526 D3ZB71_RAT (13-736): 0: 545: 96.27		D4A3W8_RAT (1-836): 0: 709: 76.94
+	Mm
		1141504 DVL2_MOUSE (13-736): 0: 550: 96.69		DACT1_MOUSE (1-836): 0: 699: 77.18
+	Rn
		88914 DVL1_RAT (11-736): 2.39e-170: 507: 57.59		D4A3W8_RAT (1-836): 0: 709: 76.94
+	Mm
		844430 DVL1_MOUSE (11-736): 5.49e-170: 506: 57.32		DACT1_MOUSE (1-836): 0: 699: 77.18
+	Mm
		1142091 DVL3_MOUSE (11-736): 4.73e-159: 479: 65.18		DACT1_MOUSE (1-836): 0: 699: 77.18
+	Rn
		88909 D4ADV8_RAT (11-732): 1.9e-154: 467: 64.44		D4A3W8_RAT (1-836): 0: 709: 76.94
+	Dr
		1163513 Q803Q5_DANRE (11-736): 7.96e-173: 515: 67.24		DACT1_DANRE (36-836): 0: 615: 47.77
+	Mm
		1141499 DVL2_MOUSE (13-736): 0: 550: 96.69		DACT2_MOUSE (34-836): 8.02e-106: 344: 25.89
+	Rn
		88525 D3ZB71_RAT (13-736): 0: 545: 96.27		D3ZSK6_RAT (35-836): 8.1e-93: 310: 25.53
+	Mm
		844426 DVL1_MOUSE (11-736): 5.49e-170: 506: 57.32		DACT2_MOUSE (34-836): 8.02e-106: 344: 25.89
+	Mm
		1142089 DVL3_MOUSE (11-736): 4.73e-159: 479: 65.18		DACT2_MOUSE (34-836): 8.02e-106: 344: 25.89
+	Rn
		88714 DVL1_RAT (11-736): 2.39e-170: 507: 57.59		D3ZSK6_RAT (35-836): 8.1e-93: 310: 25.53
+	Rn
		88704 D4ADV8_RAT (11-732): 1.9e-154: 467: 64.44		D3ZSK6_RAT (35-836): 8.1e-93: 310: 25.53
+	Mm
		1012047 DVL2_MOUSE (13-736): 0: 550: 96.69		DACT3_MOUSE (368-836): 1.28e-19: 95.6: 22.06
+	Mm
		844415 DVL1_MOUSE (11-736): 5.49e-170: 506: 57.32		DACT3_MOUSE (368-836): 1.28e-19: 95.6: 22.06
+	Mm
		1012048 DVL3_MOUSE (11-736): 4.73e-159: 479: 65.18		DACT3_MOUSE (368-836): 1.28e-19: 95.6: 22.06
+	Mm
		88458 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		D3Z656_MOUSE (425-799): 2.19e-12: 73.3: 12.91
+	Mm
		1143433 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		SYNJ1_MOUSE (425-799): 9.87e-12: 71.3: 12.23
+	Hs
		297818 AFAD_HUMAN (256-701): 1.96e-50: 193: 20.93		K0754_HUMAN (167-637): 1.15e-27: 123: 12.16