HitPredict

Interactor 1: GOSR2 (O14653)
Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin)
Gene: GOSR2

Interactor 2: STX4 (Q12846)
Syntaxin-4 (Renal carcinoma antigen NY-REN-31)
Gene: STX4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	25416956, 32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SNARE~V-SNARE_C
Common GO terms	GO:0000149 - SNARE binding GO:0005484 - SNAP receptor activity GO:0005829 - cytosol GO:0006906 - vesicle fusion GO:0016020 - membrane and 1 others more... GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 212 Hs			1 297
+	Hs
		151576 GOSR2_HUMAN (1-212): 5.78e-61: 191: 100.00		STX1A_HUMAN (1-293): 1.9e-70: 221: 43.20
+	Ce
		183452 GOSR2_CAEEL (1-210): 3.97e-58: 184: 32.70		STX1A_CAEEL (2-291): 5.07e-70: 220: 36.90
+	Dm
		1098107 GOSR2_DROME (1-211): 5.02e-53: 171: 41.12		STX1A_DROME (2-293): 8.97e-68: 214: 38.91
+	Hs
		151531 GOSR2_HUMAN (1-212): 5.78e-61: 191: 100.00		STX7_HUMAN (31-291): 4.47e-50: 167: 23.95
+	Hs
		151600 GOSR2_HUMAN (1-212): 5.78e-61: 191: 100.00		STX12_HUMAN (34-279): 2.35e-49: 166: 25.00
+	Mm
		292714 VTI1A_MOUSE (2-211): 6.63e-55: 176: 12.38		Q8BH40_MOUSE (34-291): 4.52e-53: 176: 23.85
+	Dm
		1098008 GOSR2_DROME (1-211): 5.02e-53: 171: 41.12		STX5_DROME (2-276): 1.42e-50: 174: 17.97
+	Hs
		269467 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		STX11_HUMAN (1-282): 4.21e-53: 176: 27.18
+	Hs
		152170 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		STX16_HUMAN (6-272): 8.86e-51: 171: 20.45
+	Mm
		1206468 Q91XH6_MOUSE (2-210): 9.41e-50: 163: 14.88		Q8BH40_MOUSE (34-291): 4.52e-53: 176: 23.85
+	At
		1352079 VTI12_ARATH (1-210): 7.47e-53: 171: 14.87		SYP42_ARATH (27-292): 1.73e-49: 168: 19.48
+	At
		249589 VTI12_ARATH (1-210): 7.47e-53: 171: 14.87		SYP41_ARATH (28-292): 2.73e-49: 167: 20.00
+	Hs
		178716 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		STX7_HUMAN (31-291): 4.47e-50: 167: 23.95
+	Hs
		1205352 VTI1A_HUMAN (2-210): 3.39e-52: 169: 11.96		STX12_HUMAN (34-279): 2.35e-49: 166: 25.00
+	At
		1352078 VTI12_ARATH (1-210): 7.47e-53: 171: 14.87		SYP43_ARATH (28-292): 1.49e-47: 163: 18.52
+	Mm
		250839 VTI1B_MOUSE (2-210): 1.26e-49: 162: 14.88		STX7_MOUSE (34-291): 1.27e-51: 172: 23.85
+	At
		955689 VTI12_ARATH (1-210): 7.47e-53: 171: 14.87		SYP22_ARATH (25-280): 1.17e-47: 162: 17.83
+	At
		249590 VTI11_ARATH (1-191): 2.81e-50: 164: 14.36		SYP41_ARATH (28-292): 2.73e-49: 167: 20.00
+	At
		1352080 VTI11_ARATH (1-191): 2.81e-50: 164: 14.36		SYP43_ARATH (28-292): 1.49e-47: 163: 18.52
+	At
		955690 VTI11_ARATH (1-191): 2.81e-50: 164: 14.36		SYP22_ARATH (25-280): 1.17e-47: 162: 17.83