HitPredict

Interactor 1: IRS4 (O14654)
Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
Gene: IRS4

Interactor 2: RHOQ (P17081)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
Gene: RHOQ

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0008286 - insulin receptor signaling pathway
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1257 Hs			1 205
+	Hs
		151906 IRS4_HUMAN (1-1257): 0: 1632: 100.00		RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59
+	Hs
		151770 IRS4_HUMAN (1-1257): 0: 1632: 100.00		RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97
+	Hs
		151764 IRS4_HUMAN (1-1257): 0: 1632: 100.00		RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98
+	Hs
		151754 IRS4_HUMAN (1-1257): 0: 1632: 100.00		CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57
+	Hs
		151756 IRS4_HUMAN (1-1257): 0: 1632: 100.00		RHOA_HUMAN (1-201): 1.3e-76: 230: 49.75
+	Hs
		151753 IRS4_HUMAN (1-1257): 0: 1632: 100.00		RAC3_HUMAN (10-183): 9.1e-76: 227: 66.67
+	Hs
		151762 IRS4_HUMAN (1-1257): 0: 1632: 100.00		RHOB_HUMAN (1-204): 1.77e-75: 227: 49.51
+	Hs
		916096 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		RHOB_HUMAN (1-204): 1.77e-75: 227: 49.51