HitPredict

Interactor 1: IRS4 (O14654)
Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
Gene: IRS4

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.706

Property	Details
Experiments	35271311, 36931259, 24255178, 25036637
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1257 Hs			1 246
+	Hs
		151760 IRS4_HUMAN (1-1257): 0: 1632: 100.00		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		151765 IRS4_HUMAN (1-1257): 0: 1632: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		151714 IRS4_HUMAN (1-1257): 0: 1632: 100.00		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		151758 IRS4_HUMAN (1-1257): 0: 1632: 100.00		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		151776 IRS4_HUMAN (1-1257): 0: 1632: 100.00		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		151721 IRS4_HUMAN (1-1257): 0: 1632: 100.00		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Dm
		955052 IRS1_DROME (83-354): 1.31e-71: 261: 30.00		1433E_DROME (3-245): 4.63e-144: 405: 64.90
+	Dm
		664678 IRS1_DROME (83-354): 1.31e-71: 261: 30.00		1433Z_DROME (2-246): 4.79e-141: 396: 78.78
+	Hs
		910201 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		683852 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		927703 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		724526 IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		683169 IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		647417 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		646680 IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		905303 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		982659 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		724525 IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		684422 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		683873 IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62