HitPredict

Interactor 1: IRS4 (O14654)
Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
Gene: IRS4

Interactor 2: RND3 (P61587)
Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3)
Gene: RND3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1257 Hs			1 244
+	Hs
		151744 IRS4_HUMAN (1-1257): 0: 1632: 100.00		RND2_HUMAN (20-244): 3.9e-103: 300: 64.00
+	Hs
		151762 IRS4_HUMAN (1-1257): 0: 1632: 100.00		RHOB_HUMAN (22-200): 2.38e-90: 266: 50.84
+	Hs
		151754 IRS4_HUMAN (1-1257): 0: 1632: 100.00		CDC42_HUMAN (24-208): 1.29e-82: 246: 40.00
+	Hs
		151764 IRS4_HUMAN (1-1257): 0: 1632: 100.00		RAC1_HUMAN (24-210): 3.03e-80: 240: 43.32
+	Hs
		151756 IRS4_HUMAN (1-1257): 0: 1632: 100.00		RHOA_HUMAN (25-207): 1.21e-76: 231: 50.27
+	Hs
		151753 IRS4_HUMAN (1-1257): 0: 1632: 100.00		RAC3_HUMAN (24-199): 1.42e-75: 229: 43.75
+	Hs
		151770 IRS4_HUMAN (1-1257): 0: 1632: 100.00		RHOG_HUMAN (23-208): 1.85e-74: 226: 42.47
+	Hs
		120201 IRS4_HUMAN (1-1257): 0: 1632: 100.00		RHOD_HUMAN (25-211): 1.61e-54: 176: 41.18
+	Hs
		151913 IRS4_HUMAN (1-1257): 0: 1632: 100.00		RHOF_HUMAN (25-212): 1.18e-52: 171: 45.21
+	Hs
		151704 IRS4_HUMAN (1-1257): 0: 1632: 100.00		RHOQ_HUMAN (25-212): 8.64e-51: 166: 42.02
+	Hs
		916096 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		RHOB_HUMAN (22-200): 2.38e-90: 266: 50.84