HitPredict

Interactor 1: IRS4 (O14654)
Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
Gene: IRS4

Interactor 2: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	36931259, 25036637
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1257 Hs			1 255
+	Dm
		955052 IRS1_DROME (83-354): 1.31e-71: 261: 30.00		1433E_DROME (1-254): 2.95e-146: 411: 82.69
+	Hs
		910201 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		724526 IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Mm
		724581 IRS1_MOUSE (685-1099): 2.43e-15: 83.7: 18.51		1433E_MOUSE (1-255): 4.87e-154: 430: 100.00