HitPredict

Interactor 1: IRS4 (O14654)
Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
Gene: IRS4

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	9553137, 21706016, 15316024
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0008286 - insulin receptor signaling pathway
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1257 Hs			1 217
+	Hs
		151689 IRS4_HUMAN (1-1257): 0: 1632: 100.00		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		151692 IRS4_HUMAN (1-1257): 0: 1632: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Dm
		993227 IRS1_DROME (83-354): 1.31e-71: 261: 30.00		GRAP_DROME (1-215): 5.1e-62: 194: 62.79
+	Mm
		946348 IRS2_MOUSE (601-1085): 1.63e-23: 110: 21.68		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Rn
		94388 F1MAL5_RAT (601-1085): 2.45e-23: 109: 22.37		GRB2_RAT (1-217): 6.71e-76: 229: 100.00
+	Hs
		924983 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		724527 IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		724599 IRS1_MOUSE (685-1099): 2.43e-15: 83.7: 18.51		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Rn
		724631 IRS1_RAT (685-1099): 3.05e-15: 83.3: 19.47		GRB2_RAT (1-217): 6.71e-76: 229: 100.00
+	Mm
		639440 IRS2_MOUSE (601-1085): 1.63e-23: 110: 21.68		LYN_MOUSE (129-215): 2.66e-11: 64.2: 22.47
+	Hs
		412057 IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58