HitPredict

Interactor 1: STX16 (O14662)
Syntaxin-16 (Syn16)
Gene: STX16

Interactor 2: VAMP5 (O95183)
Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)
Gene: VAMP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.936

Property	Details
Experiments	25416956, 32296183, 30833792, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, validated two hybrid, two hybrid prey pooling approach, two hybrid array, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SNARE~Synaptobrevin, Synaptobrevin~Syntaxin
Common GO terms	GO:0005794 - Golgi apparatus GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 325 Hs			1 116
+	At
		1352876 SYP43_ARATH (1-322): 3.39e-77: 241: 31.72		VA721_ARATH (5-92): 9.82e-32: 113: 26.14
+	At
		249598 SYP41_ARATH (1-322): 4.06e-77: 240: 31.27		VA721_ARATH (5-92): 9.82e-32: 113: 26.14
+	At
		1352985 SYP42_ARATH (1-322): 5.51e-76: 237: 31.69		VA721_ARATH (5-92): 9.82e-32: 113: 26.14
+	Hs
		152121 STX16_HUMAN (1-302): 3.04e-80: 248: 100.00		VAMP4_HUMAN (3-73): 1.13e-25: 95.3: 29.58
+	Hs
		152158 STX16_HUMAN (1-302): 3.04e-80: 248: 100.00		VAMP3_HUMAN (2-72): 2.01e-24: 90.7: 38.03
+	Hs
		306784 STX1B_HUMAN (49-324): 8.65e-66: 210: 20.14		VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00
+	Hs
		306800 STX1A_HUMAN (49-323): 7.31e-64: 205: 20.83		VAMP5_HUMAN (1-116): 2.4e-35: 118: 100.00
+	Rn
		699183 STX1A_RAT (49-323): 4.66e-65: 208: 20.83		VAMP7_RAT (4-96): 7.13e-26: 98: 30.11
+	Rn
		699182 STX1A_RAT (49-323): 4.66e-65: 208: 20.83		VAMP1_RAT (2-78): 9.26e-27: 97.3: 37.66
+	Hs
		620262 STX1B_HUMAN (49-324): 8.65e-66: 210: 20.14		VAMP1_HUMAN (2-78): 6.73e-26: 95: 36.36
+	Mm
		898816 STX1B_MOUSE (49-324): 8.65e-66: 210: 20.14		VAMP2_MOUSE (2-75): 2.33e-25: 93.8: 39.19
+	Hs
		898830 STX1B_HUMAN (49-324): 8.65e-66: 210: 20.14		VAMP2_HUMAN (2-75): 2.33e-25: 93.8: 39.19
+	Hs
		850569 STX1A_HUMAN (49-323): 7.31e-64: 205: 20.83		VAMP7_HUMAN (4-96): 5.88e-26: 98: 31.18
+	Mm
		192845 STX1A_MOUSE (49-323): 5.42e-65: 208: 20.83		VAMP2_MOUSE (2-75): 2.33e-25: 93.8: 39.19
+	Rn
		699175 STX1A_RAT (49-323): 4.66e-65: 208: 20.83		VAMP2_RAT (2-75): 2.33e-25: 93.8: 39.19
+	Hs
		261664 STX1A_HUMAN (49-323): 7.31e-64: 205: 20.83		VAMP4_HUMAN (3-73): 1.13e-25: 95.3: 29.58
+	Hs
		620271 STX1A_HUMAN (49-323): 7.31e-64: 205: 20.83		VAMP1_HUMAN (2-78): 6.73e-26: 95: 36.36
+	Rn
		699186 STX1A_RAT (49-323): 4.66e-65: 208: 20.83		VAMP8_RAT (2-69): 7.27e-25: 91.9: 27.94
+	Mm
		139056 STX1A_MOUSE (49-323): 5.42e-65: 208: 20.83		SC22B_MOUSE (2-86): 2.38e-23: 91.1: 17.65
+	Hs
		263248 STX1A_HUMAN (49-323): 7.31e-64: 205: 20.83		SC22B_HUMAN (2-86): 2.38e-23: 91.1: 17.65