HitPredict

Interactor 1: STX16 (O14662)
Syntaxin-16 (Syn16)
Gene: STX16

Interactor 2: SNAA (P54920)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)
Gene: NAPA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	30833792, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNAP~SNARE, SNAP~Syntaxin
Common GO terms	GO:0000149 - SNARE binding GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0016020 - membrane GO:0019905 - syntaxin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 325 Hs			1 295
+	Hs
		152174 STX16_HUMAN (1-302): 3.04e-80: 248: 100.00		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Hs
		898845 STX1B_HUMAN (49-324): 8.65e-66: 210: 20.14		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Mm
		192858 STX1A_MOUSE (49-323): 5.42e-65: 208: 20.83		SNAA_MOUSE (1-295): 2.18e-113: 330: 98.31
+	Rn
		699171 STX1A_RAT (49-323): 4.66e-65: 208: 20.83		SNAA_RAT (1-295): 8.43e-113: 329: 98.31
+	Hs
		873547 STX1A_HUMAN (49-323): 7.31e-64: 205: 20.83		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Hs
		1083986 STX1A_HUMAN (49-323): 7.31e-64: 205: 20.83		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Hs
		699286 STX2_HUMAN (46-324): 1.27e-63: 204: 19.38		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Hs
		873540 STX3_HUMAN (56-302): 1.68e-52: 176: 19.61		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Hs
		873559 STX12_HUMAN (57-309): 6.15e-53: 176: 25.00		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Hs
		1030185 STX3_HUMAN (56-302): 1.68e-52: 176: 19.61		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Hs
		1205369 STX12_HUMAN (57-309): 6.15e-53: 176: 25.00		SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25
+	Dm
		1095554 STX1A_DROME (50-323): 3.04e-60: 196: 18.69		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Dm
		1095582 Q9VR90_DROME (1-315): 1.92e-59: 196: 34.25		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Dm
		1095562 Q86P91_DROME (1-315): 4.42e-58: 193: 34.25		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Hs
		152173 STX16_HUMAN (1-302): 3.04e-80: 248: 100.00		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Sc
		696598 TLG2_YEAST (4-322): 1.92e-51: 176: 21.39		SEC17_YEAST (8-294): 4.63e-88: 266: 34.48
+	Hs
		1205360 STX12_HUMAN (57-309): 6.15e-53: 176: 25.00		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Dm
		1098094 STX1A_DROME (50-323): 3.04e-60: 196: 18.69		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Dm
		1353745 Q9VR90_DROME (1-315): 1.92e-59: 196: 34.25		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Dm
		1098102 STX1A_DROME (50-323): 3.04e-60: 196: 18.69		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53