HitPredict

Interactor 1: TMG1 (O14668)
Transmembrane gamma-carboxyglutamic acid protein 1 (Proline-rich gamma-carboxyglutamic acid protein 1) (Proline-rich Gla protein 1)
Gene: PRRG1

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	33961781, 19953087
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 218 Hs			1 1319
+	Hs
		808258 TMG3_HUMAN (4-206): 2.36e-71: 218: 36.12		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		808257 TMG4_HUMAN (4-172): 1.98e-61: 193: 28.57		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		152191 TMG1_HUMAN (1-218): 6.1e-109: 313: 100.00		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		1299622 TMG3_HUMAN (4-206): 2.36e-71: 218: 36.12		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		1299621 TMG4_HUMAN (4-172): 1.98e-61: 193: 28.57		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		152200 TMG2_HUMAN (4-172): 2.64e-45: 151: 32.39		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		152188 TMG1_HUMAN (1-218): 6.1e-109: 313: 100.00		HECW1_HUMAN (475-1317): 0: 726: 31.48
+	Hs
		1176347 TMG4_HUMAN (4-172): 1.98e-61: 193: 28.57		HECW1_HUMAN (475-1317): 0: 726: 31.48
+	Hs
		152192 TMG1_HUMAN (1-218): 6.1e-109: 313: 100.00		WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86
+	Hs
		152190 TMG1_HUMAN (1-218): 6.1e-109: 313: 100.00		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42
+	Hs
		1317816 TMG4_HUMAN (4-172): 1.98e-61: 193: 28.57		WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86
+	Hs
		152193 TMG1_HUMAN (1-218): 6.1e-109: 313: 100.00		HECW2_HUMAN (434-992): 3.07e-10: 67.1: 13.83
+	Hs
		1294852 TMG4_HUMAN (4-172): 1.98e-61: 193: 28.57		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42
+	Mm
		808369 TMG2_MOUSE (4-172): 6.31e-50: 163: 30.68		NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29