HitPredict

Interactor 1: TMG1 (O14668)
Transmembrane gamma-carboxyglutamic acid protein 1 (Proline-rich gamma-carboxyglutamic acid protein 1) (Proline-rich Gla protein 1)
Gene: PRRG1

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 218 Hs			1 903
+	Hs
		152192 TMG1_HUMAN (1-218): 6.1e-109: 313: 100.00		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		1294852 TMG4_HUMAN (4-172): 1.98e-61: 193: 28.57		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		152191 TMG1_HUMAN (1-218): 6.1e-109: 313: 100.00		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		1317816 TMG4_HUMAN (4-172): 1.98e-61: 193: 28.57		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		152184 TMG1_HUMAN (1-218): 6.1e-109: 313: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		1299622 TMG3_HUMAN (4-206): 2.36e-71: 218: 36.12		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		1299621 TMG4_HUMAN (4-172): 1.98e-61: 193: 28.57		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		152200 TMG2_HUMAN (4-172): 2.64e-45: 151: 32.39		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		808258 TMG3_HUMAN (4-206): 2.36e-71: 218: 36.12		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		808257 TMG4_HUMAN (4-172): 1.98e-61: 193: 28.57		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		152193 TMG1_HUMAN (1-218): 6.1e-109: 313: 100.00		HECW2_HUMAN (1-512): 1.38e-13: 77.2: 11.34
+	Hs
		152188 TMG1_HUMAN (1-218): 6.1e-109: 313: 100.00		HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76
+	Mm
		808369 TMG2_MOUSE (4-172): 6.31e-50: 163: 30.68		NEDD4_MOUSE (13-426): 2.27e-52: 199: 18.38
+	Hs
		1176347 TMG4_HUMAN (4-172): 1.98e-61: 193: 28.57		HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76