HitPredict

Interactor 1: TMG2 (O14669)
Transmembrane gamma-carboxyglutamic acid protein 2 (Proline-rich gamma-carboxyglutamic acid protein 2) (Proline-rich Gla protein 2)
Gene: PRRG2

Interactor 2: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.50	0.613

Property	Details
Experiments	25283809, 23873930, 17502622
Identification Methods	pull down, two hybrid, isothermal titration calorimetry
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 202 Hs			1 504
+	Hs
		152200 TMG2_HUMAN (1-202): 2.51e-90: 265: 100.00		NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73
+	Mm
		808369 TMG2_MOUSE (1-202): 6.75e-86: 253: 77.18		NEDD4_MOUSE (28-504): 2.4e-113: 357: 16.98
+	Hs
		1294852 TMG4_HUMAN (10-195): 1.33e-73: 223: 36.04		ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17
+	Hs
		1299621 TMG4_HUMAN (10-195): 1.33e-73: 223: 36.04		NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73
+	Hs
		1317816 TMG4_HUMAN (10-195): 1.33e-73: 223: 36.04		WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42
+	Hs
		808898 TMG4_HUMAN (10-195): 1.33e-73: 223: 36.04		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		808257 TMG4_HUMAN (10-195): 1.33e-73: 223: 36.04		NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26
+	Hs
		152190 TMG1_HUMAN (29-198): 2.3e-54: 174: 31.86		ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17
+	Hs
		152191 TMG1_HUMAN (29-198): 2.3e-54: 174: 31.86		NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73
+	Hs
		152192 TMG1_HUMAN (29-198): 2.3e-54: 174: 31.86		WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42
+	Hs
		152185 TMG1_HUMAN (29-198): 2.3e-54: 174: 31.86		YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00
+	Hs
		152184 TMG1_HUMAN (29-198): 2.3e-54: 174: 31.86		NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26
+	Hs
		808258 TMG3_HUMAN (29-202): 4.22e-52: 168: 28.78		NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26
+	Hs
		152201 TMG2_HUMAN (1-202): 2.51e-90: 265: 100.00		WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83
+	Hs
		1317815 TMG4_HUMAN (10-195): 1.33e-73: 223: 36.04		WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83
+	Hs
		1136436 TMG4_HUMAN (10-195): 1.33e-73: 223: 36.04		MAGI3_HUMAN (69-270): 5.85e-40: 156: 21.64
+	Hs
		1300667 TMG4_HUMAN (10-195): 1.33e-73: 223: 36.04		MAGI1_HUMAN (69-305): 1.87e-39: 155: 18.32
+	Hs
		1176347 TMG4_HUMAN (10-195): 1.33e-73: 223: 36.04		HECW1_HUMAN (2-222): 1.33e-24: 110: 14.96
+	Hs
		152188 TMG1_HUMAN (29-198): 2.3e-54: 174: 31.86		HECW1_HUMAN (2-222): 1.33e-24: 110: 14.96
+	Hs
		152193 TMG1_HUMAN (29-198): 2.3e-54: 174: 31.86		HECW2_HUMAN (13-303): 1.56e-14: 79: 14.79