HitPredict

Interactor 1: ADA10 (O14672)
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)
Gene: ADAM10

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25036101
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005102 - signaling receptor binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 748 Hs			1 377
+	Hs
		152285 ADA10_HUMAN (12-748): 0: 717: 100.00		GRAP_HUMAN (5-251): 9.35e-27: 107: 20.00
+	Hs
		152228 ADA10_HUMAN (12-748): 0: 717: 100.00		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		152233 ADA10_HUMAN (12-748): 0: 717: 100.00		HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24
+	Hs
		152297 ADA10_HUMAN (12-748): 0: 717: 100.00		SH319_HUMAN (8-254): 6.26e-19: 90.5: 19.84
+	Hs
		152242 ADA10_HUMAN (12-748): 0: 717: 100.00		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		152272 ADA10_HUMAN (12-748): 0: 717: 100.00		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		152229 ADA10_HUMAN (12-748): 0: 717: 100.00		YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27
+	Hs
		788989 ADAM9_HUMAN (35-644): 7.75e-145: 446: 21.18		TEC_HUMAN (27-377): 4.7e-38: 146: 17.63
+	Hs
		788983 ADAM8_HUMAN (4-645): 3.67e-135: 421: 19.25		TEC_HUMAN (27-377): 4.7e-38: 146: 17.63
+	Hs
		298977 ADAM9_HUMAN (35-644): 7.75e-145: 446: 21.18		SRBS2_HUMAN (64-287): 1.79e-23: 104: 18.26
+	Hs
		314542 ATS2_HUMAN (8-659): 5.11e-137: 436: 15.75		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		442890 ADA22_HUMAN (21-640): 6.54e-132: 414: 18.55		HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24
+	Hs
		522906 ADA17_HUMAN (17-647): 1.73e-136: 424: 27.90		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		522899 ADAM8_HUMAN (4-645): 3.67e-135: 421: 19.25		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		197589 ADA12_HUMAN (52-661): 5.66e-124: 394: 18.10		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		197579 ADA12_HUMAN (52-661): 5.66e-124: 394: 18.10		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		197581 ADA12_HUMAN (52-661): 5.66e-124: 394: 18.10		HCK_HUMAN (2-174): 4.07e-20: 93.7: 17.24
+	Mm
		1141131 ADA12_MOUSE (52-661): 9.74e-126: 398: 18.60		GRB2_MOUSE (1-61): 1.55e-16: 79.4: 29.03
+	Hs
		197583 ADA12_HUMAN (52-661): 5.66e-124: 394: 18.10		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		197596 ADA12_HUMAN (52-661): 5.66e-124: 394: 18.10		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81