HitPredict

Interactor 1: ADA10 (O14672)
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)
Gene: ADAM10

Interactor 2: TSN5 (P62079)
Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)
Gene: TSPAN5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	23091066, 33961781, 26686862
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005788 - endoplasmic reticulum lumen GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 748 Hs			1 268
+	Mm
		193016 ADA10_MOUSE (1-748): 0: 724: 96.00		TSN14_MOUSE (1-266): 1.45e-83: 253: 59.02
+	Hs
		152322 ADA10_HUMAN (12-748): 0: 717: 100.00		TSN17_HUMAN (1-268): 3.97e-85: 256: 78.89
+	Hs
		152312 ADA10_HUMAN (12-748): 0: 717: 100.00		TSN14_HUMAN (1-266): 3.18e-84: 254: 58.27
+	Hs
		152306 ADA10_HUMAN (12-748): 0: 717: 100.00		TSN33_HUMAN (7-264): 7.73e-76: 233: 42.64
+	Mm
		192970 ADA10_MOUSE (1-748): 0: 724: 96.00		TSN7_MOUSE (1-266): 1.77e-65: 206: 24.06
+	Mm
		100228 ADA10_MOUSE (1-748): 0: 724: 96.00		TSN15_MOUSE (14-263): 3.83e-62: 199: 32.80
+	Hs
		152215 ADA10_HUMAN (12-748): 0: 717: 100.00		TSN15_HUMAN (14-263): 1.8e-61: 197: 34.00
+	Hs
		152257 ADA10_HUMAN (12-748): 0: 717: 100.00		CD82_HUMAN (11-267): 6.94e-60: 192: 28.09
+	Hs
		152264 ADA10_HUMAN (12-748): 0: 717: 100.00		CD151_HUMAN (5-266): 2.12e-56: 182: 22.64
+	Hs
		152234 ADA10_HUMAN (12-748): 0: 717: 100.00		CD63_HUMAN (11-263): 1.04e-55: 180: 24.90
+	Hs
		152332 ADA10_HUMAN (12-748): 0: 717: 100.00		TSN10_HUMAN (1-247): 9.59e-54: 179: 36.36
+	Hs
		152213 ADA10_HUMAN (12-748): 0: 717: 100.00		TSN9_HUMAN (13-268): 5.03e-54: 176: 24.42
+	Hs
		152270 ADA10_HUMAN (12-748): 0: 717: 100.00		CD81_HUMAN (12-264): 9.13e-50: 165: 22.99
+	Hs
		152251 ADA10_HUMAN (12-748): 0: 717: 100.00		CD9_HUMAN (11-265): 6.79e-48: 160: 24.32
+	Ce
		107469 ADA10_CAEEL (23-740): 0: 546: 36.09		TSP12_CAEEL (8-268): 2.2e-67: 213: 44.16
+	Hs
		905505 ADA17_HUMAN (17-647): 1.73e-136: 424: 27.90		TSN5_HUMAN (1-268): 1.69e-88: 265: 100.00
+	Hs
		326052 ADA17_HUMAN (17-647): 1.73e-136: 424: 27.90		TSN15_HUMAN (14-263): 1.8e-61: 197: 34.00
+	Hs
		101800 F8WC54_HUMAN (35-644): 3.49e-147: 446: 21.18		CD81_HUMAN (12-264): 9.13e-50: 165: 22.99
+	Hs
		887804 ADA17_HUMAN (17-647): 1.73e-136: 424: 27.90		CD81_HUMAN (12-264): 9.13e-50: 165: 22.99
+	Hs
		602243 ADA17_HUMAN (17-647): 1.73e-136: 424: 27.90		CD9_HUMAN (11-265): 6.79e-48: 160: 24.32