HitPredict

Interactor 1: ADA10 (O14672)
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)
Gene: ADAM10

Interactor 2: PACN3 (Q9UKS6)
Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511)
Gene: PACSIN3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	25036101
Identification Methods	phage display, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 748 Hs			1 424
+	Hs
		152327 ADA10_HUMAN (12-748): 0: 717: 100.00		PACN1_HUMAN (4-422): 1.04e-84: 267: 48.86
+	Hs
		152353 ADA10_HUMAN (12-748): 0: 717: 100.00		PACN2_HUMAN (4-422): 2.86e-77: 249: 48.96
+	Hs
		152206 ADA10_HUMAN (12-748): 0: 717: 100.00		PPIP1_HUMAN (7-422): 4.41e-64: 213: 21.48
+	Hs
		152280 ADA10_HUMAN (12-748): 0: 717: 100.00		MYO1E_HUMAN (2-422): 5.28e-39: 151: 14.03
+	Hs
		152211 ADA10_HUMAN (12-748): 0: 717: 100.00		GAS7_HUMAN (363-422): 5.06e-10: 63.1: 34.43
+	Mm
		1142117 ADAM9_MOUSE (35-644): 1.57e-142: 441: 21.50		PACN3_MOUSE (1-424): 1.36e-93: 290: 94.34
+	Hs
		1034743 ADAM9_HUMAN (35-644): 7.75e-145: 446: 21.18		PACN3_HUMAN (1-424): 1.71e-91: 284: 100.00
+	Hs
		944529 ADA17_HUMAN (17-647): 1.73e-136: 424: 27.90		PACN3_HUMAN (1-424): 1.71e-91: 284: 100.00
+	Hs
		944521 ADA17_HUMAN (17-647): 1.73e-136: 424: 27.90		PACN1_HUMAN (4-422): 1.04e-84: 267: 48.86
+	Hs
		197625 ADA12_HUMAN (52-661): 5.66e-124: 394: 18.10		PACN3_HUMAN (1-424): 1.71e-91: 284: 100.00
+	Hs
		944531 ADA17_HUMAN (17-647): 1.73e-136: 424: 27.90		PACN2_HUMAN (4-422): 2.86e-77: 249: 48.96
+	Hs
		1034780 ADA15_HUMAN (54-625): 7.02e-117: 374: 20.20		PACN3_HUMAN (1-424): 1.71e-91: 284: 100.00
+	Mm
		292358 ADA15_MOUSE (58-605): 6.56e-91: 305: 20.99		PACN3_MOUSE (1-424): 1.36e-93: 290: 94.34
+	Hs
		941711 ADAM8_HUMAN (4-645): 3.67e-135: 421: 19.25		CIP4_HUMAN (16-365): 9.77e-38: 146: 17.05
+	Hs
		941713 ADAM8_HUMAN (4-645): 3.67e-135: 421: 19.25		FBP1L_HUMAN (190-421): 1.92e-12: 70.9: 13.82
+	Hs
		941717 ADAM8_HUMAN (4-645): 3.67e-135: 421: 19.25		FNBP1_HUMAN (214-421): 7.83e-12: 69: 13.46
+	Hs
		197601 ADA12_HUMAN (52-661): 5.66e-124: 394: 18.10		ITSN1_HUMAN (30-424): 3.23e-15: 80.2: 10.78
+	Hs
		1034753 ADA15_HUMAN (54-625): 7.02e-117: 374: 20.20		ITSN1_HUMAN (30-424): 3.23e-15: 80.2: 10.78
+	Hs
		1132434 ADA19_HUMAN (62-656): 2.19e-116: 375: 19.71		FBP1L_HUMAN (190-421): 1.92e-12: 70.9: 13.82
+	Hs
		305115 ADA19_HUMAN (62-656): 2.19e-116: 375: 19.71		RIMB1_HUMAN (280-423): 2.01e-09: 62.1: 18.71